Long-Term Survival of Patients with Cancer, Sepsis, and Vasopressor Requirements Based on Lactate Levels

John A. Cuenca; Joseph L. Nates; Andres Laserna; Alba J. Heatter; Nirmala Manjappachar; Peyton Martin; Maria P. Reyes; Mike Hernandez; Jacob Hall; Claudia M. Ramirez; Diego H. De Villalobos

doi:10.1097/CCE.0000000000001070

Long-Term Survival of Patients with Cancer, Sepsis, and Vasopressor Requirements Based on Lactate Levels

John A. Cuenca, Joseph L. Nates, Andres Laserna, Alba J. Heatter, Nirmala Manjappachar, Peyton Martin, Maria P. Reyes, Mike Hernandez, Jacob Hall, Claudia M. Ramirez, Diego H. De Villalobos

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A prospective cohort study was conducted to evaluate the 1-year survival of cancer patients with sepsis and vasopressor requirements. Eligible patients were admitted a Comprehensive Cancer Center's ICU and were compared based on their admission lactate levels. Of the 132 included patients, 87 (66%) had high lactate (HL; > 2.0 mmol/L), and 45 (34%) had normal lactate (NL; ≤ 2.0 mmol/L). The 1-year survival rates of the two groups were similar (HL 16% vs. NL 18%; p = 0.0921). After adjustment for ICU baseline characteristics, HL was not significantly associated with a 1-year survival (Hazards ratio, 1.39; 95% CI, 0.94-2.05). Critically ill cancer patients with sepsis and vasopressor requirements, regardless of the lactate level, had 1-year survival of less than 20%. Large multicenter cancer registries would enable to confirm our findings and better understand the long-term trajectories of sepsis in this vulnerable population.

Original language	English (US)
Pages (from-to)	E1070
Journal	Critical Care Explorations
Volume	6
Issue number	4
DOIs	https://doi.org/10.1097/CCE.0000000000001070
State	Published - Apr 2 2024

Keywords

cancer
hematological
lactate
malignancies
sepsis
septic shock
solid tumors

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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title = "Long-Term Survival of Patients with Cancer, Sepsis, and Vasopressor Requirements Based on Lactate Levels",

abstract = "A prospective cohort study was conducted to evaluate the 1-year survival of cancer patients with sepsis and vasopressor requirements. Eligible patients were admitted a Comprehensive Cancer Center's ICU and were compared based on their admission lactate levels. Of the 132 included patients, 87 (66%) had high lactate (HL; > 2.0 mmol/L), and 45 (34%) had normal lactate (NL; ≤ 2.0 mmol/L). The 1-year survival rates of the two groups were similar (HL 16% vs. NL 18%; p = 0.0921). After adjustment for ICU baseline characteristics, HL was not significantly associated with a 1-year survival (Hazards ratio, 1.39; 95% CI, 0.94-2.05). Critically ill cancer patients with sepsis and vasopressor requirements, regardless of the lactate level, had 1-year survival of less than 20%. Large multicenter cancer registries would enable to confirm our findings and better understand the long-term trajectories of sepsis in this vulnerable population.",

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author = "Cuenca, {John A.} and Nates, {Joseph L.} and Andres Laserna and Heatter, {Alba J.} and Nirmala Manjappachar and Peyton Martin and Reyes, {Maria P.} and Mike Hernandez and Jacob Hall and Ramirez, {Claudia M.} and {De Villalobos}, {Diego H.}",

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doi = "10.1097/CCE.0000000000001070",

language = "English (US)",

volume = "6",

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AU - Cuenca, John A.

AU - Nates, Joseph L.

AU - Laserna, Andres

AU - Heatter, Alba J.

AU - Manjappachar, Nirmala

AU - Martin, Peyton

AU - Reyes, Maria P.

AU - Hernandez, Mike

AU - Hall, Jacob

AU - Ramirez, Claudia M.

AU - De Villalobos, Diego H.

PY - 2024/4/2

Y1 - 2024/4/2

N2 - A prospective cohort study was conducted to evaluate the 1-year survival of cancer patients with sepsis and vasopressor requirements. Eligible patients were admitted a Comprehensive Cancer Center's ICU and were compared based on their admission lactate levels. Of the 132 included patients, 87 (66%) had high lactate (HL; > 2.0 mmol/L), and 45 (34%) had normal lactate (NL; ≤ 2.0 mmol/L). The 1-year survival rates of the two groups were similar (HL 16% vs. NL 18%; p = 0.0921). After adjustment for ICU baseline characteristics, HL was not significantly associated with a 1-year survival (Hazards ratio, 1.39; 95% CI, 0.94-2.05). Critically ill cancer patients with sepsis and vasopressor requirements, regardless of the lactate level, had 1-year survival of less than 20%. Large multicenter cancer registries would enable to confirm our findings and better understand the long-term trajectories of sepsis in this vulnerable population.

AB - A prospective cohort study was conducted to evaluate the 1-year survival of cancer patients with sepsis and vasopressor requirements. Eligible patients were admitted a Comprehensive Cancer Center's ICU and were compared based on their admission lactate levels. Of the 132 included patients, 87 (66%) had high lactate (HL; > 2.0 mmol/L), and 45 (34%) had normal lactate (NL; ≤ 2.0 mmol/L). The 1-year survival rates of the two groups were similar (HL 16% vs. NL 18%; p = 0.0921). After adjustment for ICU baseline characteristics, HL was not significantly associated with a 1-year survival (Hazards ratio, 1.39; 95% CI, 0.94-2.05). Critically ill cancer patients with sepsis and vasopressor requirements, regardless of the lactate level, had 1-year survival of less than 20%. Large multicenter cancer registries would enable to confirm our findings and better understand the long-term trajectories of sepsis in this vulnerable population.

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KW - hematological

KW - lactate

KW - malignancies

KW - sepsis

KW - septic shock

KW - solid tumors

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Long-Term Survival of Patients with Cancer, Sepsis, and Vasopressor Requirements Based on Lactate Levels

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Keywords

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