Lose weight with traditional chinese medicine? Potential suppression of fat mass and obesity-associated protein

Pei Chun Chang, Jing Doo Wang, Min Min Lee, Su Sen Chang, Tsung Ying Tsai, Kai Wei Chang, Fuu Jen Tsai, Calvin Yu Chian Chen

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations

    Abstract

    Overweight and obesity are common health problems in modern society, particularly in developed countries. Excessive body mass has been linked to numerous diseases, such as cardiovascular diseases, diabetes, and cancer. Fat mass and obesity-associated protein (FTO) activity have direct impact on food intake and results in obesity. Inhibition of FTO activity may cause weight loss and reduce obese-linked health risks. We investigated the potential weight loss effects of traditional Chinese medicine (TCM), particularly by inhibiting FTO functions. Molecular docking was performed to screen TCM compounds from TCM Database@Taiwan (http://tcm.cmu.edu.tw). Three candidates were identified that contained either a tetrahydropyridine group or potent electronegative phenol group in the structure scaffold. Molecular dynamics simulation analysis of the docking poses of each complex indicated stabilizing trends in the protein-ligand complex movements. In addition, the number of hydrogen bonds increased throughout the 20 ns simulation. These results suggest that these TCM candidates could be potential FTO inhibitors through competitive inhibition.

    Original languageEnglish (US)
    Pages (from-to)471-483
    Number of pages13
    JournalJournal of Biomolecular Structure and Dynamics
    Volume29
    Issue number3
    DOIs
    StatePublished - Dec 2011

    Keywords

    • Docking
    • FTO
    • Molecular Dynamics
    • Obesity
    • Traditional Chinese Medicine (TCM)

    ASJC Scopus subject areas

    • Structural Biology
    • Molecular Biology

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