Abstract
In a recent article, Maxwell et al. report that loss of tumor cell-specific AT-rich interaction domain 1A (ARID1A), a component of the chromatin remodeling SWI/SNF complex, triggers antitumor immunity via R-loop-mediated upregulation of the type-I interferon (IFN) pathway. These recent findings uncover a molecular mechanism underlying improved responses to immune checkpoint therapy (ICT) seen in patients harboring an ARID1A loss-of-function mutation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 568-570 |
| Number of pages | 3 |
| Journal | Trends in Immunology |
| Volume | 45 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2024 |
Keywords
- ARID1A
- Interferon
- R-loop
- STING
- anti-tumor immunity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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