Low disease activity state in rheumatoid arthritis: Concepts and derivation of minimal disease activity

George Wells; Maarten Boers; Peter Tugwell; Daniel Aletaha; Jennifer Anderson; Clair Bombardier; Peter Brooks; Maxime Dougados; Paul Emery; David Felson; Jaap Fransen; Dan Furst; Mieke Hazes; Kent Johnson; John Kirwan; Robert Landewé; Marissa Lassere; Kaleb Michaud; Beverley Shea; Maria Suarez-Almazor; Alan Silman; Lee Simon; Josef Smolen; Vibeke Strand; Desiree van der Heijde; Piet van Riel; Fred Wolfe

Low disease activity state in rheumatoid arthritis: Concepts and derivation of minimal disease activity

George Wells, Maarten Boers, Peter Tugwell, Daniel Aletaha, Jennifer Anderson, Clair Bombardier, Peter Brooks, Maxime Dougados, Paul Emery, David Felson, Jaap Fransen, Dan Furst, Mieke Hazes, Kent Johnson, John Kirwan, Robert Landewé, Marissa Lassere, Kaleb Michaud, Beverley Shea, Maria Suarez-AlmazorAlan Silman, Lee Simon, Josef Smolen, Vibeke Strand, Desiree van der Heijde, Piet van Riel, Fred Wolfe

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

With recent advances in therapy, the proportion of patients achieving a satisfactory state of minimal disease activity (MDA) is becoming a more important measure with which to compare different treatment strategies. MDA is between high disease activity and remission and anyone in remission will also be in MDA. This paper summarizes the process of coming to a definition of minimal disease activity in rheumatoid arthritis. Two equivalent preliminary definitions of minimal disease activity for use as secondary outcome measures in clinical trials in RA are proposed: a core-set definition based on the WHO/ILAR core set and a DAS-based definition based on the DAS28.

Original language	English (US)
Pages (from-to)	S52-S59
Journal	Clinical and experimental rheumatology
Volume	24
Issue number	6 SUPPL. 43
State	Published - Nov 2006

Keywords

Low disease activity state
Minimal disease activity
Rheumatoid arthritis

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology

Cite this

Wells, G., Boers, M., Tugwell, P., Aletaha, D., Anderson, J., Bombardier, C., Brooks, P., Dougados, M., Emery, P., Felson, D., Fransen, J., Furst, D., Hazes, M., Johnson, K., Kirwan, J., Landewé, R., Lassere, M., Michaud, K., Shea, B., ... Wolfe, F. (2006). Low disease activity state in rheumatoid arthritis: Concepts and derivation of minimal disease activity. Clinical and experimental rheumatology, 24(6 SUPPL. 43), S52-S59.

Wells, G, Boers, M, Tugwell, P, Aletaha, D, Anderson, J, Bombardier, C, Brooks, P, Dougados, M, Emery, P, Felson, D, Fransen, J, Furst, D, Hazes, M, Johnson, K, Kirwan, J, Landewé, R, Lassere, M, Michaud, K, Shea, B, Suarez-Almazor, M, Silman, A, Simon, L, Smolen, J, Strand, V, van der Heijde, D, van Riel, P & Wolfe, F 2006, 'Low disease activity state in rheumatoid arthritis: Concepts and derivation of minimal disease activity', Clinical and experimental rheumatology, vol. 24, no. 6 SUPPL. 43, pp. S52-S59.

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abstract = "With recent advances in therapy, the proportion of patients achieving a satisfactory state of minimal disease activity (MDA) is becoming a more important measure with which to compare different treatment strategies. MDA is between high disease activity and remission and anyone in remission will also be in MDA. This paper summarizes the process of coming to a definition of minimal disease activity in rheumatoid arthritis. Two equivalent preliminary definitions of minimal disease activity for use as secondary outcome measures in clinical trials in RA are proposed: a core-set definition based on the WHO/ILAR core set and a DAS-based definition based on the DAS28.",

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AU - Bombardier, Clair

AU - Brooks, Peter

AU - Dougados, Maxime

AU - Emery, Paul

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AU - Fransen, Jaap

AU - Furst, Dan

AU - Hazes, Mieke

AU - Johnson, Kent

AU - Kirwan, John

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AU - Silman, Alan

AU - Simon, Lee

AU - Smolen, Josef

AU - Strand, Vibeke

AU - van der Heijde, Desiree

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AU - Wolfe, Fred

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Low disease activity state in rheumatoid arthritis: Concepts and derivation of minimal disease activity

Abstract

Keywords

ASJC Scopus subject areas

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