Abstract
Background: A decreased radioiodine uptake is associated with high recurrence rate and reduced survival in papillary thyroid carcinoma (PTC). Sodium iodide symporter (NIS) expression status in aggressive PTC variants is unknown.
Methods: NIS expression in conventional PTC and aggressive PTC variants such as tall cell variant (TCV) and diffuse sclerosing variant (DSPTC) was investigated using immunohistochemical detection.
Results: Patients having TCV and DSPTC were significantly more likely to have extrathyroidal extension and lymph nodes metastases (P < 0.05). Positive NIS staining was identified in 228 of 312 (73.1 %) patients with conventional PTC, 9 of 28 (32.1 %) patients with TCV and 12 of 30 (40.0 %) patients with DSPTC. NIS expression distinguished conventional PTC from TCV and DSPTC significantly (P < 0.01).
Conclusion: Due to their low NIS expression, TCV and DSPTC need higher cumulative doses of radioactive iodine therapy to improve their prognosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 800-804 |
| Number of pages | 5 |
| Journal | International Journal of Clinical Oncology |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 16 2014 |
Keywords
- Aggressive variant papillary carcinoma
- Diffuse sclerosing
- Sodium iodide symporter
- Tall cell
- Thyroid cancer
ASJC Scopus subject areas
- Surgery
- Hematology
- Oncology
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