Low-Grade Ductal Carcinoma in Situ

Sarah A. Alghamdi; Kritika Krishnamurthy; Sofia A. Garces Narvaez; Khaled J. Algashaamy; Jessica Aoun; Isildinha M. Reis; Monica A. Recine; Merce Jorda; Robert J. Poppiti; Carmen R. Gomez-Fernandez

doi:10.1093/ajcp/aqz179

Low-Grade Ductal Carcinoma in Situ

Sarah A. Alghamdi, Kritika Krishnamurthy, Sofia A. Garces Narvaez, Khaled J. Algashaamy, Jessica Aoun, Isildinha M. Reis, Monica A. Recine, Merce Jorda, Robert J. Poppiti, Carmen R. Gomez-Fernandez

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives: We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system. Methods: Three expert breast pathologists and one junior pathologist identified low-grade DCIS from a set of 300 DCIS slides. Months later, participants were asked to grade the 300 cases using the standard three-tiered system. Results: Using the two-tiered system, interobserver agreement among breast pathologists was considered moderate (κ = 0.575). The agreement was similar (κ = 0.532) with the junior pathologist included. Using the three-tiered system, pathologists' agreement was poor (κ = 0.235). Conclusions: Pathologists' reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance.

Original language	English (US)
Pages (from-to)	360-367
Number of pages	8
Journal	American journal of clinical pathology
Volume	153
Issue number	3
DOIs	https://doi.org/10.1093/ajcp/aqz179
State	Published - Feb 8 2020
Externally published	Yes

Keywords

Ductal carcinoma in situ
Grading system
Interobserver reproducibility
Low-grade DCIS

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1093/ajcp/aqz179

Cite this

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title = "Low-Grade Ductal Carcinoma in Situ",

abstract = "Objectives: We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system. Methods: Three expert breast pathologists and one junior pathologist identified low-grade DCIS from a set of 300 DCIS slides. Months later, participants were asked to grade the 300 cases using the standard three-tiered system. Results: Using the two-tiered system, interobserver agreement among breast pathologists was considered moderate (κ = 0.575). The agreement was similar (κ = 0.532) with the junior pathologist included. Using the three-tiered system, pathologists' agreement was poor (κ = 0.235). Conclusions: Pathologists' reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance.",

keywords = "Ductal carcinoma in situ, Grading system, Interobserver reproducibility, Low-grade DCIS",

author = "Alghamdi, {Sarah A.} and Kritika Krishnamurthy and {Garces Narvaez}, {Sofia A.} and Algashaamy, {Khaled J.} and Jessica Aoun and Reis, {Isildinha M.} and Recine, {Monica A.} and Merce Jorda and Poppiti, {Robert J.} and Gomez-Fernandez, {Carmen R.}",

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doi = "10.1093/ajcp/aqz179",

language = "English (US)",

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T1 - Low-Grade Ductal Carcinoma in Situ

AU - Alghamdi, Sarah A.

AU - Krishnamurthy, Kritika

AU - Garces Narvaez, Sofia A.

AU - Algashaamy, Khaled J.

AU - Aoun, Jessica

AU - Reis, Isildinha M.

AU - Recine, Monica A.

AU - Jorda, Merce

AU - Poppiti, Robert J.

AU - Gomez-Fernandez, Carmen R.

PY - 2020/2/8

Y1 - 2020/2/8

N2 - Objectives: We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system. Methods: Three expert breast pathologists and one junior pathologist identified low-grade DCIS from a set of 300 DCIS slides. Months later, participants were asked to grade the 300 cases using the standard three-tiered system. Results: Using the two-tiered system, interobserver agreement among breast pathologists was considered moderate (κ = 0.575). The agreement was similar (κ = 0.532) with the junior pathologist included. Using the three-tiered system, pathologists' agreement was poor (κ = 0.235). Conclusions: Pathologists' reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance.

AB - Objectives: We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system. Methods: Three expert breast pathologists and one junior pathologist identified low-grade DCIS from a set of 300 DCIS slides. Months later, participants were asked to grade the 300 cases using the standard three-tiered system. Results: Using the two-tiered system, interobserver agreement among breast pathologists was considered moderate (κ = 0.575). The agreement was similar (κ = 0.532) with the junior pathologist included. Using the three-tiered system, pathologists' agreement was poor (κ = 0.235). Conclusions: Pathologists' reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance.

KW - Ductal carcinoma in situ

KW - Grading system

KW - Interobserver reproducibility

KW - Low-grade DCIS

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Low-Grade Ductal Carcinoma in Situ

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Keywords

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