Lowering mTORC1 drives CAR T-cells home in acute myeloid leukemia

Abhishek Maiti; Naval G. Daver

doi:10.1158/1078-0432.CCR-21-2574

Lowering mTORC1 drives CAR T-cells home in acute myeloid leukemia

Abhishek Maiti, Naval G. Daver

Leukemia

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Cellular therapies have demonstrated limited efficacy thus far in acute myeloid leukemia (AML). A recent study shows that mTOR complex 1 activation downregulated CXCR4 reducing marrow infiltration of EpCAM-targeting chimeric antigen receptor (CAR) T-cells in AML. Abrogating mTOR signaling by cotreatment with mTOR inhibitors during IL2-mediated ex vivo expansion upregulated CXCR4 and bolstered bone marrow migration and AML elimination by CAR T-cells.

Original language	English (US)
Pages (from-to)	5739-5741
Number of pages	3
Journal	Clinical Cancer Research
Volume	27
Issue number	21
DOIs	https://doi.org/10.1158/1078-0432.CCR-21-2574
State	Published - Nov 15 2021

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/1078-0432.CCR-21-2574

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title = "Lowering mTORC1 drives CAR T-cells home in acute myeloid leukemia",

abstract = "Cellular therapies have demonstrated limited efficacy thus far in acute myeloid leukemia (AML). A recent study shows that mTOR complex 1 activation downregulated CXCR4 reducing marrow infiltration of EpCAM-targeting chimeric antigen receptor (CAR) T-cells in AML. Abrogating mTOR signaling by cotreatment with mTOR inhibitors during IL2-mediated ex vivo expansion upregulated CXCR4 and bolstered bone marrow migration and AML elimination by CAR T-cells.",

author = "Abhishek Maiti and Daver, {Naval G.}",

note = "Funding Information: This work was supported in part by the MD Anderson Cancer Center Support Grant CA016672 from the NCI. Figure created with BioRender.com. Publisher Copyright: {\textcopyright} 2021 American Association for Cancer Research",

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AU - Maiti, Abhishek

AU - Daver, Naval G.

N1 - Funding Information: This work was supported in part by the MD Anderson Cancer Center Support Grant CA016672 from the NCI. Figure created with BioRender.com. Publisher Copyright: © 2021 American Association for Cancer Research

PY - 2021/11/15

Y1 - 2021/11/15

N2 - Cellular therapies have demonstrated limited efficacy thus far in acute myeloid leukemia (AML). A recent study shows that mTOR complex 1 activation downregulated CXCR4 reducing marrow infiltration of EpCAM-targeting chimeric antigen receptor (CAR) T-cells in AML. Abrogating mTOR signaling by cotreatment with mTOR inhibitors during IL2-mediated ex vivo expansion upregulated CXCR4 and bolstered bone marrow migration and AML elimination by CAR T-cells.

AB - Cellular therapies have demonstrated limited efficacy thus far in acute myeloid leukemia (AML). A recent study shows that mTOR complex 1 activation downregulated CXCR4 reducing marrow infiltration of EpCAM-targeting chimeric antigen receptor (CAR) T-cells in AML. Abrogating mTOR signaling by cotreatment with mTOR inhibitors during IL2-mediated ex vivo expansion upregulated CXCR4 and bolstered bone marrow migration and AML elimination by CAR T-cells.

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Lowering mTORC1 drives CAR T-cells home in acute myeloid leukemia

Abstract

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