Lung Cancer Murine Models and Methodology for Immunopreventive Study

Marco Ramos-Castaneda, Seyed Javad Moghaddam

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lung cancer is the second most common cancers in the world and remains as the cancer with the highest incidence of death (Siegel et al. CA Cancer J Clin 71(1):7–33, 2021). K-RAS mutation is one of the most common mutations in non-small-cell lung cancer (NSCLC), encompassing 15–30% of lung adenocarcinomas (Cancer Genome Atlas Research Network. Nature 511:543–550, 2014). In this chapter, we describe various murine models with the goal of studying the role of inflammation in development and promotion of lung cancer. Immunomodulatory strategies are described in detail as well as the protocols that follow the intervention for harvesting various tissue and fluids for immune-profiling.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages203-214
Number of pages12
DOIs
StatePublished - 2022

Publication series

NameMethods in Molecular Biology
Volume2435
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • COPD
  • Immunomodulation
  • K-RAS
  • Lung cancer
  • Mouse models

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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