Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation

Esperanza Romero Fernández; Guillermo Montalbán Bravo; Rosario Arrieta Gallastegui; Ana Rodríguez De la Rúa Fernández

doi:10.1016/j.lrr.2013.06.002

Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation

Esperanza Romero Fernández
, Guillermo Montalbán Bravo
, Rosario Arrieta Gallastegui
, Ana Rodríguez De la Rúa Fernández

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background and objective: The number of infused CD34+cells (CD34+. i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The study's aim was to analyze the relationship between CD34+. i, ALC and prognosis in this patients. Patients and method: Medical records of 163 patients receiving HSCT between 2005 and 2012 were reviewed. Results: We found significant and inversely proportional relationship between the CD34+. i and the days required to reach ALC≥500/μl according to the regression line: days=-0.981×number of CD34+. i+18.09. Conclusions: We have obtained a predictive model of lymphocyte recovery based recovery of CD34+. i.

Original language	English (US)
Pages (from-to)	54-57
Number of pages	4
Journal	Leukemia Research Reports
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.lrr.2013.06.002
State	Published - 2013
Externally published	Yes

Keywords

Infused CD34+ cells
Inmune reconstitution
Lymphocyte recovery
Prognosis
Stem cell autotransplantation

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.lrr.2013.06.002

Cite this

@article{fc5aee2e13484f7186aeafe32a062020,

title = "Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation",

abstract = "Background and objective: The number of infused CD34+cells (CD34+. i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The study's aim was to analyze the relationship between CD34+. i, ALC and prognosis in this patients. Patients and method: Medical records of 163 patients receiving HSCT between 2005 and 2012 were reviewed. Results: We found significant and inversely proportional relationship between the CD34+. i and the days required to reach ALC≥500/μl according to the regression line: days=-0.981{\texttimes}number of CD34+. i+18.09. Conclusions: We have obtained a predictive model of lymphocyte recovery based recovery of CD34+. i.",

keywords = "Infused CD34+ cells, Inmune reconstitution, Lymphocyte recovery, Prognosis, Stem cell autotransplantation",

author = "\{Romero Fern{\'a}ndez\}, Esperanza and Bravo, \{Guillermo Montalb{\'a}n\} and Gallastegui, \{Rosario Arrieta\} and \{De la R{\'u}a Fern{\'a}ndez\}, \{Ana Rodr{\'i}guez\}",

year = "2013",

doi = "10.1016/j.lrr.2013.06.002",

language = "English (US)",

volume = "2",

pages = "54--57",

journal = "Leukemia Research Reports",

issn = "2213-0489",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - Lymphocyte recovery and infused CD34+ cells dose

T2 - Effect on the evolution after stem cell autotransplantation

AU - Romero Fernández, Esperanza

AU - Bravo, Guillermo Montalbán

AU - Gallastegui, Rosario Arrieta

AU - De la Rúa Fernández, Ana Rodríguez

PY - 2013

Y1 - 2013

N2 - Background and objective: The number of infused CD34+cells (CD34+. i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The study's aim was to analyze the relationship between CD34+. i, ALC and prognosis in this patients. Patients and method: Medical records of 163 patients receiving HSCT between 2005 and 2012 were reviewed. Results: We found significant and inversely proportional relationship between the CD34+. i and the days required to reach ALC≥500/μl according to the regression line: days=-0.981×number of CD34+. i+18.09. Conclusions: We have obtained a predictive model of lymphocyte recovery based recovery of CD34+. i.

AB - Background and objective: The number of infused CD34+cells (CD34+. i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The study's aim was to analyze the relationship between CD34+. i, ALC and prognosis in this patients. Patients and method: Medical records of 163 patients receiving HSCT between 2005 and 2012 were reviewed. Results: We found significant and inversely proportional relationship between the CD34+. i and the days required to reach ALC≥500/μl according to the regression line: days=-0.981×number of CD34+. i+18.09. Conclusions: We have obtained a predictive model of lymphocyte recovery based recovery of CD34+. i.

KW - Infused CD34+ cells

KW - Inmune reconstitution

KW - Lymphocyte recovery

KW - Prognosis

KW - Stem cell autotransplantation

UR - https://www.scopus.com/pages/publications/84887933002

UR - https://www.scopus.com/pages/publications/84887933002#tab=citedBy

U2 - 10.1016/j.lrr.2013.06.002

DO - 10.1016/j.lrr.2013.06.002

M3 - Article

C2 - 24371781

AN - SCOPUS:84887933002

SN - 2213-0489

VL - 2

SP - 54

EP - 57

JO - Leukemia Research Reports

JF - Leukemia Research Reports

IS - 2

ER -

Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation

Abstract

Keywords

ASJC Scopus subject areas

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