TY - JOUR
T1 - Magneto-photo-acoustic imaging
AU - Qu, Min
AU - Mallidi, Srivalleesha
AU - Mehrmohammadi, Mohammad
AU - Truby, Ryan
AU - Homan, Kimberly
AU - Joshi, Pratixa
AU - Chen, Yun Sheng
AU - Sokolov, Konstantin
AU - Emelianov, Stanislav
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Magneto-photo-acoustic imaging, a technique based on the synergy of magneto-motive ultrasound, photoacoustic and ultrasound imaging, is introduced. Hybrid nanoconstructs, liposomes encapsulating gold nanorods and iron oxide nanoparticles, were used as a dual-contrast agent for magneto-photo-acoustic imaging. Tissue-mimicking phantom and macrophage cells embedded in ex vivo porcine tissue were used to demonstrate that magneto-photo-acoustic imaging is capable of visualizing the location of cells or tissues labeled with dual-contrast nanoparticles with sufficient contrast, excellent contrast resolution and high spatial resolution in the context of the anatomical structure of the surrounding tissues. Therefore, magneto-photo-acoustic imaging is capable of identifying the nanoparticle-labeled pathological regions from the normal tissue, providing a promising platform to noninvasively diagnose and characterize pathologies.
AB - Magneto-photo-acoustic imaging, a technique based on the synergy of magneto-motive ultrasound, photoacoustic and ultrasound imaging, is introduced. Hybrid nanoconstructs, liposomes encapsulating gold nanorods and iron oxide nanoparticles, were used as a dual-contrast agent for magneto-photo-acoustic imaging. Tissue-mimicking phantom and macrophage cells embedded in ex vivo porcine tissue were used to demonstrate that magneto-photo-acoustic imaging is capable of visualizing the location of cells or tissues labeled with dual-contrast nanoparticles with sufficient contrast, excellent contrast resolution and high spatial resolution in the context of the anatomical structure of the surrounding tissues. Therefore, magneto-photo-acoustic imaging is capable of identifying the nanoparticle-labeled pathological regions from the normal tissue, providing a promising platform to noninvasively diagnose and characterize pathologies.
UR - http://www.scopus.com/inward/record.url?scp=79960867361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960867361&partnerID=8YFLogxK
U2 - 10.1364/BOE.2.000385
DO - 10.1364/BOE.2.000385
M3 - Article
AN - SCOPUS:79960867361
SN - 2156-7085
VL - 2
SP - 385
EP - 396
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 2
ER -