Malignant rhabdoid tumor arising from a pleomorphic adenoma

Kar Ming Fung, Eduardo M Diaz Jr, Adel K El-Naggar, Mario A. Luna

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Malignant transformation of pleomorphic adenomas often occurs in long-standing tumors or tumors with multiple local recurrences. The malignant component is usually a carcinoma. The case reported herein concerns a 60-year-old man who had a malignant rhabdoid tumor arising in a painless parotid mass that remained untreated for 25 years. Malignant rhabdoid tumors are clinically aggressive neoplasms with phenotypic features that resemble rhabdomyomatous differentiation but lack genuine skeletal muscle differentiation. The salient features of rhabdoid tumor cell include large, pleomorphic, and eccentric nucleus and a solitary and prominent intracytoplasmic inclusion that is strongly immunoreactive for vimentin. It is our understanding that this is the first reported case of malignant rhabdoid tumor arising in the parotid gland in the English literature. The pathologic features of our case will be discussed in context with malignant rhabdoid tumors from other parts of the body.

Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalAnnals of Diagnostic Pathology
Volume8
Issue number3
DOIs
StatePublished - Jun 1 2004

Fingerprint

Rhabdoid Tumor
Pleomorphic Adenoma
Literature
Neoplasms
Solitary Nucleus
Parotid Gland
Vimentin
Human Body
Skeletal Muscle
Carcinoma
Recurrence

Keywords

  • Carcinoma ex pleomorphic adenoma
  • malignant rhabdoid tumor
  • rhabdoid phenotype
  • tumor of salivary gland
  • vimentin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Malignant rhabdoid tumor arising from a pleomorphic adenoma. / Fung, Kar Ming; Diaz Jr, Eduardo M; El-Naggar, Adel K; Luna, Mario A.

In: Annals of Diagnostic Pathology, Vol. 8, No. 3, 01.06.2004, p. 156-161.

Research output: Contribution to journalArticle

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AU - Diaz Jr, Eduardo M

AU - El-Naggar, Adel K

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N2 - Malignant transformation of pleomorphic adenomas often occurs in long-standing tumors or tumors with multiple local recurrences. The malignant component is usually a carcinoma. The case reported herein concerns a 60-year-old man who had a malignant rhabdoid tumor arising in a painless parotid mass that remained untreated for 25 years. Malignant rhabdoid tumors are clinically aggressive neoplasms with phenotypic features that resemble rhabdomyomatous differentiation but lack genuine skeletal muscle differentiation. The salient features of rhabdoid tumor cell include large, pleomorphic, and eccentric nucleus and a solitary and prominent intracytoplasmic inclusion that is strongly immunoreactive for vimentin. It is our understanding that this is the first reported case of malignant rhabdoid tumor arising in the parotid gland in the English literature. The pathologic features of our case will be discussed in context with malignant rhabdoid tumors from other parts of the body.

AB - Malignant transformation of pleomorphic adenomas often occurs in long-standing tumors or tumors with multiple local recurrences. The malignant component is usually a carcinoma. The case reported herein concerns a 60-year-old man who had a malignant rhabdoid tumor arising in a painless parotid mass that remained untreated for 25 years. Malignant rhabdoid tumors are clinically aggressive neoplasms with phenotypic features that resemble rhabdomyomatous differentiation but lack genuine skeletal muscle differentiation. The salient features of rhabdoid tumor cell include large, pleomorphic, and eccentric nucleus and a solitary and prominent intracytoplasmic inclusion that is strongly immunoreactive for vimentin. It is our understanding that this is the first reported case of malignant rhabdoid tumor arising in the parotid gland in the English literature. The pathologic features of our case will be discussed in context with malignant rhabdoid tumors from other parts of the body.

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