Mallory bodies in experimental animals and man

H. Denk, Werner W. Franke, D. Kerjaschki, R. Eckerstorfer

    Research output: Contribution to journalArticle

    79 Scopus citations

    Abstract

    MBs have attracted and intrigued pathologists since they were first described. Although not specific for alcohol-induced liver disease. MBs most probably are the result of a unique model in which liver cells react to certain injuries, and studies on their structure and pathologic significance may contribute to our understanding of as yet unknown mechanisms involved in liver cell injury. Therefore, it is most important, in our opinion, to find the common denominator which directs MB formation in diverse hepatic disorders. The GF-mouse model, in which classical MBs can be produced under controlled conditions, is especially valuable for such studies. Since MB filaments contain prekeratin-like polypeptides, as demonstrated by immunomorphologic and biochemical techniques, they are related to, but not strictly identical to, the tonofilament subclass of intermediate-sized filaments. In consequence of our findings, we regard MB formation as a form of pathologic keratinization that is almost specific to the liver, and this assumption will determine the direction of our future research.

    Original languageEnglish (US)
    Pages (from-to)77-121
    Number of pages45
    JournalInternational Review of Experimental Pathology
    VolumeVol.20
    StatePublished - Jan 1 1979

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Physiology

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    Denk, H., Franke, W. W., Kerjaschki, D., & Eckerstorfer, R. (1979). Mallory bodies in experimental animals and man. International Review of Experimental Pathology, Vol.20, 77-121.