@inbook{8a780f842ffe440ba3bd6869e7c8d1d1,
title = "Mammalian uterine morphogenesis and variations",
abstract = "In eutherian and marsupial mammals, the site of embryo implantation and gestation is the uterus. Uterine morphologies vary between mammalian species. For example, laboratory mice have a bipartite uterus with two uterine horns and a single cervix, whereas humans have a simplex uterus with a single chamber and single cervix. The precursor tissue of the uterus, oviducts, and upper vagina is the M{\"u}llerian duct epithelium and its adjacent mesenchyme. Morphological variation between species is established during embryogenesis by species-specific differences in M{\"u}llerian duct fusion at the midline, growth, and differentiation. In humans, alterations in M{\"u}llerian duct development can lead to variations in uterine morphology that correlate with increased risks of miscarriage and infertility. Here we review the developmental genetic factors that regulate M{\"u}llerian duct development, uterine morphogenesis, and human uterine variation.",
keywords = "Bicornuate, Bipartite, Duplex, M{\"u}llerian duct, Simplex",
author = "Machado, {Diana A.} and Ontiveros, {Alejandra E.} and Behringer, {Richard R.}",
note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.ctdb.2021.12.004",
language = "English (US)",
isbn = "9780128171318",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc.",
pages = "51--77",
editor = "Thomas Gridley",
booktitle = "Mouse Models of Development and Disease",
}