TY - JOUR
T1 - Management of Borderline Resectable Pancreatic Cancer
AU - Katz, Matthew H.G.
AU - Crane, Christopher H.
AU - Varadhachary, Gauri
PY - 2014/4
Y1 - 2014/4
N2 - Borderline resectable pancreatic cancers are those that, although technically resectable, are at high risk for margin-positive resection following surgery de novo. Generally, such cancers are characterized by localized primary tumors that involve the mesenteric vasculature to a limited degree and that may require venous or hepatic arterial resection at pancreatectomy. In this article, we review diagnosis and staging algorithms, pretreatment strategies, and multidisciplinary treatment protocols for patients with this stage of disease. The rationale for and results following treatment with neoadjuvant chemotherapy and chemoradiation and subsequent surgical resection of the primary tumor are described in detail and existing data are reviewed.
AB - Borderline resectable pancreatic cancers are those that, although technically resectable, are at high risk for margin-positive resection following surgery de novo. Generally, such cancers are characterized by localized primary tumors that involve the mesenteric vasculature to a limited degree and that may require venous or hepatic arterial resection at pancreatectomy. In this article, we review diagnosis and staging algorithms, pretreatment strategies, and multidisciplinary treatment protocols for patients with this stage of disease. The rationale for and results following treatment with neoadjuvant chemotherapy and chemoradiation and subsequent surgical resection of the primary tumor are described in detail and existing data are reviewed.
UR - http://www.scopus.com/inward/record.url?scp=84895889311&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895889311&partnerID=8YFLogxK
U2 - 10.1016/j.semradonc.2013.11.006
DO - 10.1016/j.semradonc.2013.11.006
M3 - Review article
C2 - 24635867
AN - SCOPUS:84895889311
SN - 1053-4296
VL - 24
SP - 105
EP - 112
JO - Seminars in radiation oncology
JF - Seminars in radiation oncology
IS - 2
ER -