Management of Borderline Resectable Pancreatic Cancer

Matthew H.G. Katz, Christopher H. Crane, Gauri Varadhachary

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

Borderline resectable pancreatic cancers are those that, although technically resectable, are at high risk for margin-positive resection following surgery de novo. Generally, such cancers are characterized by localized primary tumors that involve the mesenteric vasculature to a limited degree and that may require venous or hepatic arterial resection at pancreatectomy. In this article, we review diagnosis and staging algorithms, pretreatment strategies, and multidisciplinary treatment protocols for patients with this stage of disease. The rationale for and results following treatment with neoadjuvant chemotherapy and chemoradiation and subsequent surgical resection of the primary tumor are described in detail and existing data are reviewed.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalSeminars in radiation oncology
Volume24
Issue number2
DOIs
StatePublished - Apr 2014

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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