Management of Hereditary Site-Specific Colon Cancer

Henry T. Lynch; Randall E. Harris; Wadi A. Bardawil; Patrick M. Lynch; Hoda A. Guirgis; Milton J. Swartz; Jane F. Lynch

doi:10.1001/archsurg.1977.01370020064007

Management of Hereditary Site-Specific Colon Cancer

Henry T. Lynch, Randall E. Harris, Wadi A. Bardawil, Patrick M. Lynch, Hoda A. Guirgis, Milton J. Swartz, Jane F. Lynch

Research output: Contribution to journal › Article › peer-review

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Abstract

A family with site-specific colon cancer and discrete adenomatous colon polyps in certain members has provided a prototype for the study and clinical management of hereditary cancer. Analysis of this kindred showed an autosomal dominant mode of inheritance, early onset of cancer with predilection for the right colon, and frequent extraprimary cancers of the colon. Knowledge of these phenomena are critical to the management of this hereditary cancer syndrome. On our recommendation, two brothers of the family who were treated for colon cancer by hemicolectomy underwent prophylactic total colectomy. The resected colon from one of these patients had an occult adenocarcinoma in a villoglandular polyp. (Arch Surg 112:170-174, 1977).

Original language	English (US)
Pages (from-to)	170-174
Number of pages	5
Journal	Archives of Surgery
Volume	112
Issue number	2
DOIs	https://doi.org/10.1001/archsurg.1977.01370020064007
State	Published - Feb 1977
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1977.01370020064007

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title = "Management of Hereditary Site-Specific Colon Cancer",

abstract = "A family with site-specific colon cancer and discrete adenomatous colon polyps in certain members has provided a prototype for the study and clinical management of hereditary cancer. Analysis of this kindred showed an autosomal dominant mode of inheritance, early onset of cancer with predilection for the right colon, and frequent extraprimary cancers of the colon. Knowledge of these phenomena are critical to the management of this hereditary cancer syndrome. On our recommendation, two brothers of the family who were treated for colon cancer by hemicolectomy underwent prophylactic total colectomy. The resected colon from one of these patients had an occult adenocarcinoma in a villoglandular polyp. (Arch Surg 112:170-174, 1977).",

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AU - Lynch, Henry T.

AU - Harris, Randall E.

AU - Bardawil, Wadi A.

AU - Lynch, Patrick M.

AU - Guirgis, Hoda A.

AU - Swartz, Milton J.

AU - Lynch, Jane F.

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AB - A family with site-specific colon cancer and discrete adenomatous colon polyps in certain members has provided a prototype for the study and clinical management of hereditary cancer. Analysis of this kindred showed an autosomal dominant mode of inheritance, early onset of cancer with predilection for the right colon, and frequent extraprimary cancers of the colon. Knowledge of these phenomena are critical to the management of this hereditary cancer syndrome. On our recommendation, two brothers of the family who were treated for colon cancer by hemicolectomy underwent prophylactic total colectomy. The resected colon from one of these patients had an occult adenocarcinoma in a villoglandular polyp. (Arch Surg 112:170-174, 1977).

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Management of Hereditary Site-Specific Colon Cancer

Abstract

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