Management of localized gastric cancer

Mariela A. Blum, Taketa Takashi, Akihiro Suzuki, Jaffer A. Ajani

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Gastric cancer continues to be a fatal disease with majority of cases presenting in late stages. For patients with advanced disease, we can only recommend palliative therapy. For localized gastric cancer, the approaches vary in various regions of the world. In western countries, preoperative chemotherapy or adjuvant chemo-radiation is preferred; however in Asia, surgery followed by adjuvant chemotherapy is favored. The extent of the lymph node dissection also varies by region. D2 gastrectomy is difficult to implement in most western countries while it is standardized and is a routine in Asia. We recommend multidisciplinary evaluation of each patient before starting any therapy. The prognosis after resection depends of the pathologic stage. Long-term survivors are often <50% in the West and <70% in many Asian countries. Regional and systemic recurrences are common. Improved systemic treatments are needed. Detailed studies of molecular biology might uncover novel therapeutic targets and prognostic subgroups. J. Surg. Oncol. 2013;107:265-270. © 2013 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalJournal of surgical oncology
Volume107
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • D2 gastrectomy
  • gastric adenocarcinoma
  • localized gastric cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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