Management of metastatic brain tumors: A review

Raymond E Sawaya, B. Lee Ligon, Alexandra Flowers, Rajesh Bindal

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Brain metastases are the most common neurological complication of systemic cancer, a serious cause of morbidity and mortality, and a significant challenge for neurosurgeons and neurooncologists. They outnumber all other intracranial tumors combined and, with advances in technology and treatment of systemic cancer, are on the increase as cancer patients live longer. This review discusses the factors that influence their occurrence in the central nervous system, namely primary cancer, age, and sex; clinical aspects of presentation; and the basic diagnostic modalities, computed tomography and mag¬netic resonance imaging. These aspects are presented along with an emphasis on the efficacy of different treatment options, including recent information that broadens the scope of surgical implications. Although radiation therapy re¬mains the main therapeutic modality, surgical excision has increasingly shown advantages in certain settings, as has stereotactic radiosurgery. Chemotherapy is less effective, but its advantages are reviewed, as are the implications of recurrent metastases. This review concludes with a separate section on the special concerns of leptomeningeal metastases.

Original languageEnglish (US)
Pages (from-to)140-157
Number of pages18
JournalNeurosurgery Quarterly
Volume4
Issue number3
DOIs
StatePublished - Jan 1 1994

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Brain Neoplasms
Neoplasms
Neoplasm Metastasis
Radiosurgery
Radiotherapy
Central Nervous System
Tomography
Magnetic Resonance Imaging
Technology
Morbidity
Drug Therapy
Mortality
Brain
Therapeutics

Keywords

  • Leptomeningeal metastases
  • Metastases

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Management of metastatic brain tumors : A review. / Sawaya, Raymond E; Ligon, B. Lee; Flowers, Alexandra; Bindal, Rajesh.

In: Neurosurgery Quarterly, Vol. 4, No. 3, 01.01.1994, p. 140-157.

Research output: Contribution to journalArticle

Sawaya, Raymond E ; Ligon, B. Lee ; Flowers, Alexandra ; Bindal, Rajesh. / Management of metastatic brain tumors : A review. In: Neurosurgery Quarterly. 1994 ; Vol. 4, No. 3. pp. 140-157.
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