Management of Recurrent Well-Differentiated Thyroid Carcinoma in the Neck: A Comprehensive Review †

Beatriz G. Cavalheiro; Jatin P. Shah; Gregory W. Randolph; Jesus E. Medina; Ralph P. Tufano; Mark Zafereo; Dana M. Hartl; Iain J. Nixon; Orlando Guntinas-Lichius; Vincent Vander Poorten; Fernando López; Avi Hefetz Khafif; Randall P. Owen; Ashok Shaha; Juan P. Rodrigo; Alessandra Rinaldo; Antti A. Mäkitie; Carl E. Silver; Alvaro Sanabria; Luiz P. Kowalski; Alfio Ferlito

doi:10.3390/cancers15030923

Management of Recurrent Well-Differentiated Thyroid Carcinoma in the Neck: A Comprehensive Review †

Beatriz G. Cavalheiro, Jatin P. Shah, Gregory W. Randolph, Jesus E. Medina, Ralph P. Tufano, Mark Zafereo, Dana M. Hartl, Iain J. Nixon, Orlando Guntinas-Lichius, Vincent Vander Poorten, Fernando López, Avi Hefetz Khafif, Randall P. Owen, Ashok Shaha, Juan P. Rodrigo, Alessandra Rinaldo, Antti A. Mäkitie, Carl E. Silver, Alvaro Sanabria, Luiz P. KowalskiAlfio Ferlito

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Surgery has been historically the preferred primary treatment for patients with well-differentiated thyroid carcinoma and for selected locoregional recurrences. Adjuvant therapy with radioactive iodine is typically recommended for patients with an intermediate to high risk of recurrence. Despite these treatments, locally advanced disease and locoregional relapses are not infrequent. These patients have a prolonged overall survival that may result in long periods of active disease and the possibility of requiring subsequent treatments. Recently, many new options have emerged as salvage therapies. This review offers a comprehensive discussion and considerations regarding surgery, active surveillance, radioactive iodine therapy, ultrasonography-guided percutaneous ablation, external beam radiotherapy, and systemic therapy for well-differentiated thyroid cancer based on relevant publications and current reference guidelines. We feel that the surgical member of the thyroid cancer management team is empowered by being aware and facile with all management options.

Original language	English (US)
Article number	923
Journal	Cancers
Volume	15
Issue number	3
DOIs	https://doi.org/10.3390/cancers15030923
State	Published - Feb 2023

Keywords

metastasis
molecular targeted therapy
neck dissection
neoadjuvant therapy
papillary thyroid cancer
radiofrequency ablation
radiotherapy
recurrence
surgery
thyroid neoplasm

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers15030923

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Cavalheiro, B. G., Shah, J. P., Randolph, G. W., Medina, J. E., Tufano, R. P., Zafereo, M., Hartl, D. M., Nixon, I. J., Guntinas-Lichius, O., Vander Poorten, V., López, F., Khafif, A. H., Owen, R. P., Shaha, A., Rodrigo, J. P., Rinaldo, A., Mäkitie, A. A., Silver, C. E., Sanabria, A., ... Ferlito, A. (2023). Management of Recurrent Well-Differentiated Thyroid Carcinoma in the Neck: A Comprehensive Review †. Cancers, 15(3), Article 923. https://doi.org/10.3390/cancers15030923

Cavalheiro, BG, Shah, JP, Randolph, GW, Medina, JE, Tufano, RP, Zafereo, M, Hartl, DM, Nixon, IJ, Guntinas-Lichius, O, Vander Poorten, V, López, F, Khafif, AH, Owen, RP, Shaha, A, Rodrigo, JP, Rinaldo, A, Mäkitie, AA, Silver, CE, Sanabria, A, Kowalski, LP & Ferlito, A 2023, 'Management of Recurrent Well-Differentiated Thyroid Carcinoma in the Neck: A Comprehensive Review †', Cancers, vol. 15, no. 3, 923. https://doi.org/10.3390/cancers15030923

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abstract = "Surgery has been historically the preferred primary treatment for patients with well-differentiated thyroid carcinoma and for selected locoregional recurrences. Adjuvant therapy with radioactive iodine is typically recommended for patients with an intermediate to high risk of recurrence. Despite these treatments, locally advanced disease and locoregional relapses are not infrequent. These patients have a prolonged overall survival that may result in long periods of active disease and the possibility of requiring subsequent treatments. Recently, many new options have emerged as salvage therapies. This review offers a comprehensive discussion and considerations regarding surgery, active surveillance, radioactive iodine therapy, ultrasonography-guided percutaneous ablation, external beam radiotherapy, and systemic therapy for well-differentiated thyroid cancer based on relevant publications and current reference guidelines. We feel that the surgical member of the thyroid cancer management team is empowered by being aware and facile with all management options.",

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AU - Rodrigo, Juan P.

AU - Rinaldo, Alessandra

AU - Mäkitie, Antti A.

AU - Silver, Carl E.

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AU - Kowalski, Luiz P.

AU - Ferlito, Alfio

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Management of Recurrent Well-Differentiated Thyroid Carcinoma in the Neck: A Comprehensive Review †

Abstract

Keywords

ASJC Scopus subject areas

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