Marital status and survival of patients with oral cavity squamous cell carcinoma: A population-based study

Xiao Shi, Ting Ting Zhang, Wei Ping Hu, Qing Hai Ji

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The relationship between marital status and oral cavity squamous cell carcinoma (OCSCC) survival has not been explored. The objective of our study was to evaluate the impact of marital status on OCSCC survival and investigate the potential mechanisms. Results: Married patients had better 5-year cancer-specific survival (CSS) (66.7% vs 54.9%) and 5-year overall survival (OS) (56.0% vs 41.1%). In multivariate Cox regression models, unmarried patients also showed higher mortality risk for both CSS (Hazard Ratio [HR]: 1.260, 95% confidence interval (CI): 1.187-1.339, P < 0.001) and OS (HR: 1.328, 95% CI: 1.266-1.392, P < 0.001). Multivariate logistic regression showed married patients were more likely to be diagnosed at earlier stage (P < 0.001) and receive surgery (P < 0.001). Married patients still demonstrated better prognosis in the 1:1 matched group analysis (CSS: 62.9% vs 60.8%, OS: 52.3% vs 46.5%). Materials and Methods: 11022 eligible OCSCC patients were identified from Surveillance, Epidemiology, and End Results (SEER) database, including 5902 married and 5120 unmarried individuals. Kaplan-Meier analysis, Log-rank test and Cox proportional hazards regression model were used to analyze survival and mortality risk. Influence of marital status on stage, age at diagnosis and selection of treatment was determined by binomial and multinomial logistic regression. Propensity score matching method was adopted to perform a 1:1 matched cohort. Conclusions: Marriage has an independently protective effect on OCSCC survival. Earlier diagnosis and more sufficient treatment are possible explanations. Besides, even after 1:1 matching, survival advantage of married group still exists, indicating that spousal support from other aspects may also play an important role.

Original languageEnglish (US)
Pages (from-to)28526-28543
Number of pages18
JournalOncotarget
Volume8
Issue number17
DOIs
StatePublished - Jan 1 2017

Fingerprint

Marital Status
Mouth
Squamous Cell Carcinoma
Survival
Population
Cell Survival
Proportional Hazards Models
Logistic Models
Confidence Intervals
Neoplasms
Propensity Score
Mortality
Kaplan-Meier Estimate
Survival Analysis
Marriage
Early Diagnosis
Epidemiology
Research Design
Databases
Therapeutics

Keywords

  • Marital status
  • Oral cavity squamous cell carcinoma
  • SEER
  • Spousal support
  • Survival analysis

ASJC Scopus subject areas

  • Oncology

Cite this

Marital status and survival of patients with oral cavity squamous cell carcinoma : A population-based study. / Shi, Xiao; Zhang, Ting Ting; Hu, Wei Ping; Ji, Qing Hai.

In: Oncotarget, Vol. 8, No. 17, 01.01.2017, p. 28526-28543.

Research output: Contribution to journalArticle

Shi, Xiao ; Zhang, Ting Ting ; Hu, Wei Ping ; Ji, Qing Hai. / Marital status and survival of patients with oral cavity squamous cell carcinoma : A population-based study. In: Oncotarget. 2017 ; Vol. 8, No. 17. pp. 28526-28543.
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abstract = "Background: The relationship between marital status and oral cavity squamous cell carcinoma (OCSCC) survival has not been explored. The objective of our study was to evaluate the impact of marital status on OCSCC survival and investigate the potential mechanisms. Results: Married patients had better 5-year cancer-specific survival (CSS) (66.7{\%} vs 54.9{\%}) and 5-year overall survival (OS) (56.0{\%} vs 41.1{\%}). In multivariate Cox regression models, unmarried patients also showed higher mortality risk for both CSS (Hazard Ratio [HR]: 1.260, 95{\%} confidence interval (CI): 1.187-1.339, P < 0.001) and OS (HR: 1.328, 95{\%} CI: 1.266-1.392, P < 0.001). Multivariate logistic regression showed married patients were more likely to be diagnosed at earlier stage (P < 0.001) and receive surgery (P < 0.001). Married patients still demonstrated better prognosis in the 1:1 matched group analysis (CSS: 62.9{\%} vs 60.8{\%}, OS: 52.3{\%} vs 46.5{\%}). Materials and Methods: 11022 eligible OCSCC patients were identified from Surveillance, Epidemiology, and End Results (SEER) database, including 5902 married and 5120 unmarried individuals. Kaplan-Meier analysis, Log-rank test and Cox proportional hazards regression model were used to analyze survival and mortality risk. Influence of marital status on stage, age at diagnosis and selection of treatment was determined by binomial and multinomial logistic regression. Propensity score matching method was adopted to perform a 1:1 matched cohort. Conclusions: Marriage has an independently protective effect on OCSCC survival. Earlier diagnosis and more sufficient treatment are possible explanations. Besides, even after 1:1 matching, survival advantage of married group still exists, indicating that spousal support from other aspects may also play an important role.",
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