Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

Cynthia L. Courtney; Kelly F. Ethun; Francois Villinger; Ruth M. Ruprecht; Siddappa N. Byrareddy

doi:10.1111/jmp.12142

Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

Cynthia L. Courtney
, Kelly F. Ethun
, Francois Villinger
, Ruth M. Ruprecht
, Siddappa N. Byrareddy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals. Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.

Original language	English (US)
Pages (from-to)	35-39
Number of pages	5
Journal	Journal of medical primatology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1111/jmp.12142
State	Published - Feb 1 2015
Externally published	Yes

Keywords

Pulmonary arterial hypertension
SHIV
SIV

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

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10.1111/jmp.12142

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title = "Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus",

abstract = "Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (\textasciitilde{}1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals. Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.",

keywords = "Pulmonary arterial hypertension, SHIV, SIV",

author = "Courtney, \{Cynthia L.\} and Ethun, \{Kelly F.\} and Francois Villinger and Ruprecht, \{Ruth M.\} and Byrareddy, \{Siddappa N.\}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley \& Sons A/S. Published by John Wiley \& Sons Ltd.",

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doi = "10.1111/jmp.12142",

language = "English (US)",

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AU - Courtney, Cynthia L.

AU - Ethun, Kelly F.

AU - Villinger, Francois

AU - Ruprecht, Ruth M.

AU - Byrareddy, Siddappa N.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals. Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.

AB - Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals. Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.

KW - Pulmonary arterial hypertension

KW - SHIV

KW - SIV

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IS - 1

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Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

Abstract

Keywords

ASJC Scopus subject areas

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