Mechanisms associated with biogenesis of exosomes in cancer

Kathleen M. McAndrews; Raghu Kalluri

doi:10.1186/s12943-019-0963-9

Mechanisms associated with biogenesis of exosomes in cancer

Kathleen M. McAndrews, Raghu Kalluri

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

256 Scopus citations

Abstract

Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer.

Original language	English (US)
Article number	52
Journal	Molecular cancer
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12943-019-0963-9
State	Published - Mar 30 2019

Keywords

Biogenesis
Cancer
Exosomes

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research

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10.1186/s12943-019-0963-9

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abstract = "Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer.",

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AB - Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer.

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KW - Exosomes

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Mechanisms associated with biogenesis of exosomes in cancer

Abstract

Keywords

ASJC Scopus subject areas

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