Mechanisms of action of anti-VEGF therapy

Lee M. Ellis

Mechanisms of action of anti-VEGF therapy

Lee M. Ellis

Surgical Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

In summary, the proposed mechanisms of action of anti-VEGF therapy include normalization of tumor vasculature shortly after the initiation of treatment, direct action upon tumor cells, and inhibition of NO and the resulting tumor vasoconstriction. While the exact mechanism(s) have yet to be determined, the clinical relevance of anti-VEGF therapy has been proven in studies showing significant improvements in RR, and in some cases OS, when anti-VEGF therapy is added to chemotherapy.

Original language	English (US)
Pages (from-to)	4-5
Number of pages	2
Journal	Clinical Advances in Hematology and Oncology
Volume	3
Issue number	7 SUPPL. 7
State	Published - Jul 2005

ASJC Scopus subject areas

Hematology
Oncology

Cite this

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title = "Mechanisms of action of anti-VEGF therapy",

abstract = "In summary, the proposed mechanisms of action of anti-VEGF therapy include normalization of tumor vasculature shortly after the initiation of treatment, direct action upon tumor cells, and inhibition of NO and the resulting tumor vasoconstriction. While the exact mechanism(s) have yet to be determined, the clinical relevance of anti-VEGF therapy has been proven in studies showing significant improvements in RR, and in some cases OS, when anti-VEGF therapy is added to chemotherapy.",

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AB - In summary, the proposed mechanisms of action of anti-VEGF therapy include normalization of tumor vasculature shortly after the initiation of treatment, direct action upon tumor cells, and inhibition of NO and the resulting tumor vasoconstriction. While the exact mechanism(s) have yet to be determined, the clinical relevance of anti-VEGF therapy has been proven in studies showing significant improvements in RR, and in some cases OS, when anti-VEGF therapy is added to chemotherapy.

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M3 - Article

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SN - 1543-0790

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JO - Clinical Advances in Hematology and Oncology

JF - Clinical Advances in Hematology and Oncology

IS - 7 SUPPL. 7

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Mechanisms of action of anti-VEGF therapy

Abstract

ASJC Scopus subject areas

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