MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B.K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi, Roland F. Schwarz

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplotype-specific somatic copy-number alterations from single-cell or bulk data. MEDICC2 eschews simplifications such as the infinite sites assumption, allowing multiple mutations and parallel evolution, and does not treat adjacent loci as independent, allowing overlapping copy-number events. Using simulations and multiple data types from 2780 tumors, we use MEDICC2 to demonstrate accurate inference of phylogenies, clonal and subclonal WGD, and ancestral copy-number states.

Original languageEnglish (US)
Article number241
JournalGenome biology
Volume23
Issue number1
DOIs
StatePublished - Dec 2022

Keywords

  • Aneuploidy
  • Cancer evolution
  • Chromosomal instability
  • Intratumor heterogeneity
  • Phylogenetic reconstruction
  • Single-cell sequencing
  • Somatic copy-number alterations
  • Whole-genome doubling

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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