Melanoma Brain Metastases: Current Areas of Investigation and Future Directions

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37 Scopus citations

Abstract

Metastases to the central nervous system (CNS) are one of the most common and lethal complications of metastatic melanoma. Historically, melanoma patients with CNS metastases have had dismal outcomes and very limited treatment options. However, the development of more effective targeted, immune, and radiation therapies is now leading to promising new investigations and strategies. Optimizing the development and testing of such strategies will benefit from an improved understanding of the unique molecular features of these tumors and the influence of the brain microenvironment. Accounting for unique clinical features and challenges of CNS metastases will also be critical to making significant clinical impact in patients.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalCancer Journal (United States)
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Brain metastasis
  • immunotherapy
  • leptomeningeal disease
  • melanoma
  • radiation therapy
  • targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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