Membranous Nephropathy Post Immune Checkpoint Inhibitors

Ala Abudayyeh; Adi Diab; Amanda Tchakarov

doi:10.1007/978-3-031-83533-9_39

Membranous Nephropathy Post Immune Checkpoint Inhibitors

Ala Abudayyeh
, Adi Diab
, Amanda Tchakarov

Melanoma Medical Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We presented a patient with history of autoimmune disease of the kidney which was reactivated after cancer diagnosis and exacerbated with immune checkpoint inhibitor (ICI) treatment. Patient’s reactivation of membranous nephropathy was due to a secondary cause which was the dual ICI therapy for his metastatic melanoma. Rituximab achieved excellent response and resolution of proteinuria after one cycle which was maintained on ICI for over 2 years with no exacerbation of his membranous nephropathy.

Original language	English (US)
Title of host publication	Challenging Cases in Immunotherapy Related Organ Toxicities
Publisher	Springer Science+Business Media
Pages	301-305
Number of pages	5
ISBN (Electronic)	9783031835339
ISBN (Print)	9783031835322
DOIs	https://doi.org/10.1007/978-3-031-83533-9_39
State	Published - Jan 1 2025

Keywords

Acute kidney injury
Immunotherapy
Membranous nephropathy
Proteinuria
Rituximab

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-031-83533-9_39

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N2 - We presented a patient with history of autoimmune disease of the kidney which was reactivated after cancer diagnosis and exacerbated with immune checkpoint inhibitor (ICI) treatment. Patient’s reactivation of membranous nephropathy was due to a secondary cause which was the dual ICI therapy for his metastatic melanoma. Rituximab achieved excellent response and resolution of proteinuria after one cycle which was maintained on ICI for over 2 years with no exacerbation of his membranous nephropathy.

AB - We presented a patient with history of autoimmune disease of the kidney which was reactivated after cancer diagnosis and exacerbated with immune checkpoint inhibitor (ICI) treatment. Patient’s reactivation of membranous nephropathy was due to a secondary cause which was the dual ICI therapy for his metastatic melanoma. Rituximab achieved excellent response and resolution of proteinuria after one cycle which was maintained on ICI for over 2 years with no exacerbation of his membranous nephropathy.

KW - Acute kidney injury

KW - Immunotherapy

KW - Membranous nephropathy

KW - Proteinuria

KW - Rituximab

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BT - Challenging Cases in Immunotherapy Related Organ Toxicities

PB - Springer Science+Business Media

ER -

Membranous Nephropathy Post Immune Checkpoint Inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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