TY - JOUR
T1 - Menopausal hormone therapy does not influence lung cancer risk
T2 - Results from the California Teachers Study
AU - Clague, Jessica
AU - Reynolds, Peggy
AU - Sullivan-Halley, Jane
AU - Ma, Huiyan
AU - Lacey, James V.
AU - Henderson, Katherine D.
AU - Ursin, Giske
AU - West, Dee
AU - Chang, Shine
AU - Delclos, George L.
AU - Du, Xianglin L.
AU - Forman, Michele R.
AU - Bernstein, Leslie
PY - 2011/3
Y1 - 2011/3
N2 - Background: Results from studies examining the association between hormone therapy (HT) and lung cancer risk disagree. Methods: We examined the associations between HT use and lung cancer risk among 60,592 postmenopausal women enrolled in the prospective California Teachers Study cohort. Between 1995 and 2007, a total of 727 women had a diagnosis of lung cancer. Multivariable Cox proportional hazards regression models were fit using age as the time metric. Results: No measure of HT use was associated with lung cancer risk (all Ptrend values ≥0.4). In addition, no variations in risk by smoking status (never, ever, former, current), type of HT [estrogen (E)-alone, E + progestin (P) use], type of menopause, or lung cancer histology were observed. Conclusions: Our findings do not support an association between HT and lung cancer. Impact: This large-scale, prospective study, which capitalizes on the detailed hormone use, smoking history, and type of menopause information available within this unique cohort, was unable to find any association between intake of HT and lung cancer risk.
AB - Background: Results from studies examining the association between hormone therapy (HT) and lung cancer risk disagree. Methods: We examined the associations between HT use and lung cancer risk among 60,592 postmenopausal women enrolled in the prospective California Teachers Study cohort. Between 1995 and 2007, a total of 727 women had a diagnosis of lung cancer. Multivariable Cox proportional hazards regression models were fit using age as the time metric. Results: No measure of HT use was associated with lung cancer risk (all Ptrend values ≥0.4). In addition, no variations in risk by smoking status (never, ever, former, current), type of HT [estrogen (E)-alone, E + progestin (P) use], type of menopause, or lung cancer histology were observed. Conclusions: Our findings do not support an association between HT and lung cancer. Impact: This large-scale, prospective study, which capitalizes on the detailed hormone use, smoking history, and type of menopause information available within this unique cohort, was unable to find any association between intake of HT and lung cancer risk.
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U2 - 10.1158/1055-9965.EPI-10-1182
DO - 10.1158/1055-9965.EPI-10-1182
M3 - Article
C2 - 21266521
AN - SCOPUS:79955759416
SN - 1055-9965
VL - 20
SP - 560
EP - 564
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 3
ER -