Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Leila Lujan-Barroso, Wei Zhang, Sara H. Olson, Yu Tang Gao, Herbert Yu, Peter A. Baghurst, Paige M. Bracci, H. Bas Bueno-De-Mesquita, Lenka Foretová, Steven Gallinger, Ivana Holcatova, Vladimír Janout, Bu Tian Ji, Robert C. Kurtz, Carlo La Vecchia, Pagona Lagiou, Donghui Li, Anthony B. Miller, Diego Serraino, Witold ZatonskiHarvey A. Risch, Eric J. Duell

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objectives: We aimed to evaluate the relation between menstrual and reproductive factors, exogenous hormones, and risk of pancreatic cancer (PC). Methods: Eleven case-control studies within the International Pancreatic Cancer Case-control Consortium took part in the present study, including in total 2838 case and 4748 controlwomen. Pooled estimates of odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a 2-step logistic regression model and adjusting for relevant covariates. Results: An inverse ORwas observed inwomenwho reported having had hysterectomy (ORyesvs.no, 0.78; 95% CI, 0.67-0.91), remaining significant in postmenopausalwomen and never-smoking women, adjusted for potential PC confounders. A mutually adjusted model with the joint effect for hormone replacement therapy (HRT) and hysterectomy showed significant inverse associations with PC in women who reported having had hysterectomy with HRT use (OR, 0.64; 95% CI, 0.48-0.84). Conclusions: Our large pooled analysis suggests that women who have had a hysterectomy may have reduced risk of PC. However, we cannot rule out that the reduced risk could be due to factors or indications for having had a hysterectomy. Further investigation of risk according to HRT use and reason for hysterectomy may be necessary.

Original languageEnglish (US)
Pages (from-to)1401-1410
Number of pages10
JournalPancreas
Volume45
Issue number10
DOIs
StatePublished - Nov 1 2016

Keywords

  • consortium
  • exogenous hormones
  • hysterectomy
  • menstrual and reproductive factors
  • pancreatic cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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