TY - JOUR
T1 - Merging Orthovoltage X-Ray Minibeams spare the proximal tissues while producing a solid beam at the target
AU - Dilmanian, F. Avraham
AU - Krishnan, Sunil
AU - McLaughlin, William E.
AU - Lukaniec, Brendan
AU - Baker, Jameson T.
AU - Ailawadi, Sandeep
AU - Hirsch, Kara N.
AU - Cattell, Renee F.
AU - Roy, Rahul
AU - Helfer, Joel
AU - Kruger, Kurt
AU - Spuhler, Karl
AU - He, Yulun
AU - Tailor, Ramesh
AU - Vassantachart, April
AU - Heaney, Dakota C.
AU - Zanzonico, Pat
AU - Gobbert, Matthias K.
AU - Graf, Jonathan S.
AU - Nassimi, Jessica R.
AU - Fatemi, Nasrin N.
AU - Schweitzer, Mark E.
AU - Bangiyev, Lev
AU - Eley, John G.
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Conventional radiation therapy of brain tumors often produces cognitive deficits, particularly in children. We investigated the potential efficacy of merging Orthovoltage X-ray Minibeams (OXM). It segments the beam into an array of parallel, thin (~0.3 mm), planar beams, called minibeams, which are known from synchrotron x-ray experiments to spare tissues. Furthermore, the slight divergence of the OXM array make the individual minibeams gradually broaden, thus merging with their neighbors at a given tissue depth to produce a solid beam. In this way the proximal tissues, including the cerebral cortex, can be spared. Here we present experimental results with radiochromic films to characterize the method’s dosimetry. Furthermore, we present our Monte Carlo simulation results for physical absorbed dose, and a first-order biologic model to predict tissue tolerance. In particular, a 220-kVp orthovoltage beam provides a 5-fold sharper lateral penumbra than a 6-MV x-ray beam. The method can be implemented in arc-scan, which may include volumetric-modulated arc therapy (VMAT). Finally, OXM’s low beam energy makes it ideal for tumor-dose enhancement with contrast agents such as iodine or gold nanoparticles, and its low cost, portability, and small room-shielding requirements make it ideal for use in the low-and-middle-income countries.
AB - Conventional radiation therapy of brain tumors often produces cognitive deficits, particularly in children. We investigated the potential efficacy of merging Orthovoltage X-ray Minibeams (OXM). It segments the beam into an array of parallel, thin (~0.3 mm), planar beams, called minibeams, which are known from synchrotron x-ray experiments to spare tissues. Furthermore, the slight divergence of the OXM array make the individual minibeams gradually broaden, thus merging with their neighbors at a given tissue depth to produce a solid beam. In this way the proximal tissues, including the cerebral cortex, can be spared. Here we present experimental results with radiochromic films to characterize the method’s dosimetry. Furthermore, we present our Monte Carlo simulation results for physical absorbed dose, and a first-order biologic model to predict tissue tolerance. In particular, a 220-kVp orthovoltage beam provides a 5-fold sharper lateral penumbra than a 6-MV x-ray beam. The method can be implemented in arc-scan, which may include volumetric-modulated arc therapy (VMAT). Finally, OXM’s low beam energy makes it ideal for tumor-dose enhancement with contrast agents such as iodine or gold nanoparticles, and its low cost, portability, and small room-shielding requirements make it ideal for use in the low-and-middle-income countries.
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U2 - 10.1038/s41598-018-37733-x
DO - 10.1038/s41598-018-37733-x
M3 - Article
C2 - 30718607
AN - SCOPUS:85061026543
SN - 2045-2322
VL - 9
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 1198
ER -