Mesenchymal stem cells in cancer: Tumor-associated fibroblasts and cell-based delivery vehicles

Brett Hall; Jennifer Dembinski; A. Kate Sasser; Matus Studeny; Michael Andreeff; Frank Marini

doi:10.1532/IJH97.06230

Mesenchymal stem cells in cancer: Tumor-associated fibroblasts and cell-based delivery vehicles

Brett Hall, Jennifer Dembinski, A. Kate Sasser, Matus Studeny, Michael Andreeff, Frank Marini

Leukemia

Research output: Contribution to journal › Review article › peer-review

155 Scopus citations

Abstract

Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anticancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

Original language	English (US)
Pages (from-to)	8-16
Number of pages	9
Journal	International journal of hematology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1532/IJH97.06230
State	Published - Jul 2007

Keywords

Gene therapy
Mesenchymal stem cells
Stroma
Tumor microenvironment
Vascular network

ASJC Scopus subject areas

Hematology

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10.1532/IJH97.06230

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abstract = "Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anticancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.",

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AU - Dembinski, Jennifer

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AU - Studeny, Matus

AU - Andreeff, Michael

AU - Marini, Frank

PY - 2007/7

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N2 - Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anticancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

AB - Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anticancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

KW - Gene therapy

KW - Mesenchymal stem cells

KW - Stroma

KW - Tumor microenvironment

KW - Vascular network

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Mesenchymal stem cells in cancer: Tumor-associated fibroblasts and cell-based delivery vehicles

Abstract

Keywords

ASJC Scopus subject areas

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