Abstract
Mesenchymal stem/stroma cells (MSCs) exhibit an innate tropism and capacity to migrate to sites of inflammation including wounding damage and the tumor microenvironment, where they have been shown to contribute to the development of tumor-associated stroma. Recent data suggest the tumor microenvironment plays a critical role in tumor progression in that both local tissue- and bone marrow-derived mesenchyme interact with tumor cells, which then provokes signaling responses that is thought to support tumor growth. Numerous reports demonstrate that sites of tissue damage secrete elevated levels of inflammatory mediators much like those found in the tumor microenvironment, which then stimulates recruitment and engraftment of MSC. This chapter will describe the emerging role of MSCs in tumor stroma development, describe their ability to home to and engraft in the tumor microenvironment, as well as how we can best employ stromal cells by using them as gene delivery vehicles directing them to sites of tumor formation to control tumor growth.
Original language | English (US) |
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Title of host publication | Targeted Therapy of Acute Myeloid Leukemi |
Publisher | Springer New York |
Pages | 799-819 |
Number of pages | 21 |
ISBN (Electronic) | 9781493913930 |
ISBN (Print) | 9781493913923 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- Anticancer
- Cell vehicle
- Inflammation
- Stroma
- Tumor homing
- Tumor microenvironment
ASJC Scopus subject areas
- General Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology