Mesenchymal stem/stromal cell-targeted therapies for solid tumors and hematological malignancies

Christopher H. Booth, Lysette Mutkus, Karen Bussard, Erika Spaeth, Michael Andreeff, Frank C. Marini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mesenchymal stem/stroma cells (MSCs) exhibit an innate tropism and capacity to migrate to sites of inflammation including wounding damage and the tumor microenvironment, where they have been shown to contribute to the development of tumor-associated stroma. Recent data suggest the tumor microenvironment plays a critical role in tumor progression in that both local tissue- and bone marrow-derived mesenchyme interact with tumor cells, which then provokes signaling responses that is thought to support tumor growth. Numerous reports demonstrate that sites of tissue damage secrete elevated levels of inflammatory mediators much like those found in the tumor microenvironment, which then stimulates recruitment and engraftment of MSC. This chapter will describe the emerging role of MSCs in tumor stroma development, describe their ability to home to and engraft in the tumor microenvironment, as well as how we can best employ stromal cells by using them as gene delivery vehicles directing them to sites of tumor formation to control tumor growth.

Original languageEnglish (US)
Title of host publicationTargeted Therapy of Acute Myeloid Leukemi
PublisherSpringer New York
Pages799-819
Number of pages21
ISBN (Electronic)9781493913930
ISBN (Print)9781493913923
DOIs
StatePublished - Jan 1 2015

Keywords

  • Anticancer
  • Cell vehicle
  • Inflammation
  • Stroma
  • Tumor homing
  • Tumor microenvironment

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

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