Mesenchymal stromal cells and umbilical cord blood transplantation

Chitra Hosing; Marcos De Lima; Elizabeth J. Shpall

doi:10.1007/978-1-61779-630-2_4

Mesenchymal stromal cells and umbilical cord blood transplantation

Chitra Hosing, Marcos De Lima, Elizabeth J. Shpall

Stem Cell Transplantation

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

In recent years umbilical cord blood has become an important source of stem cells for patients undergoing hematopoietic stem cell transplantation. Ease of collection, ready availability, allowance of higher HLA disparity, and the lower incidence of graft-versus-host disease makes cord blood an attractive source of stem cells, especially for minority populations. One of the major limitations to wider use of umbilical cord stem cells for transplantation in adult patients is the relative low number of progenitor cells in the graft. This results in delayed engraftment, delayed immune reconstitution, and increased rates of infectious complications. This can be partly overcome by ex vivo expansion of cord blood stem cells. There are many techniques for cord blood expansion currently being used in clinical trials, but the optimal expansion protocol has yet to be defined. Here we discuss ex vivo expansion using mesenchymal stromal cells.

Original language	English (US)
Title of host publication	Adult and Embryonic Stem Cells
Publisher	Humana Press Inc.
Pages	33-47
Number of pages	15
ISBN (Electronic)	9781617796302
ISBN (Print)	9781617796296
DOIs	https://doi.org/10.1007/978-1-61779-630-2_4
State	Published - Jan 1 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-1-61779-630-2_4

Cite this

@inbook{d4b591d1f44a4dadb7438094dd61ca45,

title = "Mesenchymal stromal cells and umbilical cord blood transplantation",

abstract = "In recent years umbilical cord blood has become an important source of stem cells for patients undergoing hematopoietic stem cell transplantation. Ease of collection, ready availability, allowance of higher HLA disparity, and the lower incidence of graft-versus-host disease makes cord blood an attractive source of stem cells, especially for minority populations. One of the major limitations to wider use of umbilical cord stem cells for transplantation in adult patients is the relative low number of progenitor cells in the graft. This results in delayed engraftment, delayed immune reconstitution, and increased rates of infectious complications. This can be partly overcome by ex vivo expansion of cord blood stem cells. There are many techniques for cord blood expansion currently being used in clinical trials, but the optimal expansion protocol has yet to be defined. Here we discuss ex vivo expansion using mesenchymal stromal cells.",

author = "Chitra Hosing and {De Lima}, Marcos and Shpall, {Elizabeth J.}",

year = "2012",

month = jan,

day = "1",

doi = "10.1007/978-1-61779-630-2_4",

language = "English (US)",

isbn = "9781617796296",

pages = "33--47",

booktitle = "Adult and Embryonic Stem Cells",

publisher = "Humana Press Inc.",

}

TY - CHAP

T1 - Mesenchymal stromal cells and umbilical cord blood transplantation

AU - Hosing, Chitra

AU - De Lima, Marcos

AU - Shpall, Elizabeth J.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - In recent years umbilical cord blood has become an important source of stem cells for patients undergoing hematopoietic stem cell transplantation. Ease of collection, ready availability, allowance of higher HLA disparity, and the lower incidence of graft-versus-host disease makes cord blood an attractive source of stem cells, especially for minority populations. One of the major limitations to wider use of umbilical cord stem cells for transplantation in adult patients is the relative low number of progenitor cells in the graft. This results in delayed engraftment, delayed immune reconstitution, and increased rates of infectious complications. This can be partly overcome by ex vivo expansion of cord blood stem cells. There are many techniques for cord blood expansion currently being used in clinical trials, but the optimal expansion protocol has yet to be defined. Here we discuss ex vivo expansion using mesenchymal stromal cells.

AB - In recent years umbilical cord blood has become an important source of stem cells for patients undergoing hematopoietic stem cell transplantation. Ease of collection, ready availability, allowance of higher HLA disparity, and the lower incidence of graft-versus-host disease makes cord blood an attractive source of stem cells, especially for minority populations. One of the major limitations to wider use of umbilical cord stem cells for transplantation in adult patients is the relative low number of progenitor cells in the graft. This results in delayed engraftment, delayed immune reconstitution, and increased rates of infectious complications. This can be partly overcome by ex vivo expansion of cord blood stem cells. There are many techniques for cord blood expansion currently being used in clinical trials, but the optimal expansion protocol has yet to be defined. Here we discuss ex vivo expansion using mesenchymal stromal cells.

UR - http://www.scopus.com/inward/record.url?scp=85026312419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026312419&partnerID=8YFLogxK

U2 - 10.1007/978-1-61779-630-2_4

DO - 10.1007/978-1-61779-630-2_4

M3 - Chapter

AN - SCOPUS:85026312419

SN - 9781617796296

SP - 33

EP - 47

BT - Adult and Embryonic Stem Cells

PB - Humana Press Inc.

ER -

Mesenchymal stromal cells and umbilical cord blood transplantation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this