@inbook{67072d2ad78144aab9a205ae3e3bffcf,
title = "Mesenchymal Stromal Cells and Umbilical Cord Blood Transplantation",
abstract = "In recent years umbilical cord blood has become an important source of stem cells for patients undergoing hematopoietic stem cell transplantation. Ease of collection, ready availability, allowance of higher HLA disparity, and the lower incidence of graft-versus-host disease makes cord blood an attractive source of stem cells, especially for minority populations. One of the major limitations to wider use of umbilical cord stem cells for transplantation in adult patients is the relative low number of progenitor cells in the graft. This results in delayed engraftment, delayed immune reconstitution, and increased rates of infectious complications. This can be partly overcome by ex vivo expansion of cord blood stem cells. There are many techniques for cord blood expansion currently being used in clinical trials, but the optimal expansion protocol has yet to be defined. Here we discuss ex vivo expansion using mesenchymal stromal cells.",
keywords = "Human Leukocyte Antigen, Mesenchymal Stromal Cell, Stem Cell Factor, Total Nucleate Cell, Umbilical Cord Blood",
author = "Chitra Hosing and \{de Lima\}, Marcos and Shpall, \{Elizabeth J.\}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC 2012.",
year = "2012",
doi = "10.1007/978-1-61779-630-2\_4",
language = "English (US)",
series = "Stem Cell Biology and Regenerative Medicine",
publisher = "Springer Nature",
pages = "33--47",
booktitle = "Stem Cell Biology and Regenerative Medicine",
address = "United States",
}