Meta-analysis of adjunctive non-NK1 receptor antagonist medications for the control of acute and delayed chemotherapy-induced nausea and vomiting

Thaiana Aragão Santana, Damila Cristina Trufelli, Leandro Luongo de Matos, Felipe Melo Cruz, Auro del Giglio

    Research output: Contribution to journalReview article

    3 Scopus citations

    Abstract

    Purpose: Chemotherapy-induced nausea and vomiting (CINV) is a distressing chemotherapy-induced symptom that may adversely impact the quality of life of cancer patients.

    Methods: We conducted a systematic search of the Pubmed, Bireme, and Cochrane databases for randomized clinical trials that were published in English and that evaluated the combination of adjunctive non-neurokinin 1 (NK1) antagonist drugs (i.e., neuroleptics, anticonvulsants, benzodiazepines, and cannabinoids) with 5-hydroxytryptamine 3 (5-HT3) antagonists for adult cancer patients who were scheduled to receive moderate or highly emetogenic chemotherapy. We employed the Review Manager (RevMan) Computer program Version 5.2 for statistical calculations.

    Results: We included 13 studies with a total of 1,669 patients. We observed a higher complete protection for acute CINV with adjunctive medications (risk ratio (RR) = 0.55; 95 % confidence interval (CI) 0.30–1.01; p = 0.05; I2 = 47 %), which was not the case for the delayed period (RR = 0.89; 95 % CI 0.73–1.10, p = 0.29, I2 = 15 %). We also observed that these adjunctive medications significantly increased the complete control of nausea (RR = 0.72; 95 % CI 0.55–0.95; p = 0.02, I2 = 83 %) and vomiting (RR = 0.61; 95 % CI 0.50–0.75; p < 0.00001; I2 = 60 %). There was no subgroup analysis evidence of the superiority of any single group of adjunctive medications.

    Conclusions: We conclude that adjunctive non-NK1 antagonist medications may be useful for CINV control. Prospective randomized studies incorporating these low-cost medications into new regimens combining 5-HT3 and NK1 antagonists may be warranted.

    Original languageEnglish (US)
    Pages (from-to)213-222
    Number of pages10
    JournalSupportive Care in Cancer
    Volume23
    Issue number1
    DOIs
    StatePublished - Jan 1 2015

    Keywords

    • Anticonvulsants
    • Antipsychotic agents
    • Benzodiazepines
    • Chemotherapy
    • Nausea
    • Vomiting

    ASJC Scopus subject areas

    • Oncology

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