Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy

Shivanand Pudakalakatti, Priyank Raj, Travis C. Salzillo, José S. Enriquez, Dontrey Bourgeois, Prasanta Dutta, Mark Titus, Shayan Shams, Priya Bhosale, Michael Kim, Florencia McAllister, Pratip K. Bhattacharya

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is an unmet need for noninvasive surrogate markers that can help identify premalignant lesions across different tumor types. Here we describe the methodology and technical details of protocols employed for in vivo13C pyruvate metabolic imaging experiments. The goal of the method described is to identify and understand metabolic changes, to enable detection of pancreatic premalignant lesions, as a proof of concept of the high sensitivity of this imaging modality.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages169-180
Number of pages12
DOIs
StatePublished - 2022

Publication series

NameMethods in Molecular Biology
Volume2435
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Assessment of preventive responses
  • C
  • Early detection
  • HP-MR
  • Hyperpolarization
  • MRI
  • Metabolic imaging
  • Premalignancy

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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