TY - JOUR
T1 - Metaplastic Breast Cancer
T2 - Clinical Overview and Molecular Aberrations for Potential Targeted Therapy
AU - Abouharb, Sausan
AU - Moulder, Stacy
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/3
Y1 - 2015/3
N2 - Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared to patients with standard invasive ductal carcinoma. Limited data are available in regards to best treatment modalities, including chemotherapy. This review gives an overview of metaplastic breast cancer and its clinical and pathologic characteristics, in addition to treatment strategies, clinical trials, and future directions.
AB - Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared to patients with standard invasive ductal carcinoma. Limited data are available in regards to best treatment modalities, including chemotherapy. This review gives an overview of metaplastic breast cancer and its clinical and pathologic characteristics, in addition to treatment strategies, clinical trials, and future directions.
KW - Carcinosarcoma
KW - Metaplastic breast cancer
KW - Metaplastic carcinoma
KW - Sarcomatoid carcinoma of the breast
UR - http://www.scopus.com/inward/record.url?scp=84923645568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923645568&partnerID=8YFLogxK
U2 - 10.1007/s11912-014-0431-z
DO - 10.1007/s11912-014-0431-z
M3 - Review article
C2 - 25691085
AN - SCOPUS:84923645568
SN - 1523-3790
VL - 17
SP - 1
EP - 7
JO - Current oncology reports
JF - Current oncology reports
IS - 3
ER -