Metaplastic Breast Cancer: Clinical Overview and Molecular Aberrations for Potential Targeted Therapy

Sausan Abouharb, Stacy Moulder

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared to patients with standard invasive ductal carcinoma. Limited data are available in regards to best treatment modalities, including chemotherapy. This review gives an overview of metaplastic breast cancer and its clinical and pathologic characteristics, in addition to treatment strategies, clinical trials, and future directions.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalCurrent oncology reports
Volume17
Issue number3
DOIs
StatePublished - Mar 2015

Keywords

  • Carcinosarcoma
  • Metaplastic breast cancer
  • Metaplastic carcinoma
  • Sarcomatoid carcinoma of the breast

ASJC Scopus subject areas

  • Oncology

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