Metastasis results from preexisting variant cells within a malignant tumor

Isaiah J. Fidler; Margaret L. Kripke

doi:10.1126/science.887927

Metastasis results from preexisting variant cells within a malignant tumor

Isaiah J. Fidler, Margaret L. Kripke

Research output: Contribution to journal › Article › peer-review

1187 Scopus citations

Abstract

Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population.

Original language	English (US)
Pages (from-to)	893-895
Number of pages	3
Journal	Science
Volume	197
Issue number	4306
DOIs	https://doi.org/10.1126/science.887927
State	Published - 1977
Externally published	Yes

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title = "Metastasis results from preexisting variant cells within a malignant tumor",

abstract = "Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population.",

author = "Fidler, {Isaiah J.} and Kripke, {Margaret L.}",

year = "1977",

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AU - Fidler, Isaiah J.

AU - Kripke, Margaret L.

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AB - Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population.

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Metastasis results from preexisting variant cells within a malignant tumor

Abstract

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