Metastatic Melanoma of the Optic Nerve Sheath

Neil M. D’souza; Huy D. Nguyen; Stacy V. Smith; Priyadharsini Nagarajan; Adi Diab; Richard C. Allen; Dan S. Gombos; Andrew G. Lee

doi:10.1080/01658107.2017.1372488

Metastatic Melanoma of the Optic Nerve Sheath

Neil M. D’souza, Huy D. Nguyen, Stacy V. Smith, Priyadharsini Nagarajan, Adi Diab, Richard C. Allen, Dan S. Gombos, Andrew G. Lee

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A 23-year-old man with a history of metastatic melanoma developed painful vision loss to counting fingers with enhancement of optic nerve on contrast-enhanced magnetic resonance imaging (MRI) and received a diagnosis of optic neuritis from an outside hospital. Despite empiric corticosteroid therapy, the patient worsened and developed secondary central retinal vein occlusion with further deterioration of vision. Repeat MRI demonstrated optic nerve sheath (ONS) involvement suggestive of optic perineuritis (OPN) and an ONS biopsy confirmed a rare case of isolated metastatic melanoma. Our case highlights the clinical and radiographic features that can mimic OPN and delay diagnosis and treatment.

Original language	English (US)
Pages (from-to)	187-190
Number of pages	4
Journal	Neuro-Ophthalmology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1080/01658107.2017.1372488
State	Published - May 4 2018

Keywords

Metastatic melanoma
ocular melanoma
ocular metastases
optic nerve sheath
optic perineuritis

ASJC Scopus subject areas

Ophthalmology
Clinical Neurology

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10.1080/01658107.2017.1372488

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title = "Metastatic Melanoma of the Optic Nerve Sheath",

abstract = "A 23-year-old man with a history of metastatic melanoma developed painful vision loss to counting fingers with enhancement of optic nerve on contrast-enhanced magnetic resonance imaging (MRI) and received a diagnosis of optic neuritis from an outside hospital. Despite empiric corticosteroid therapy, the patient worsened and developed secondary central retinal vein occlusion with further deterioration of vision. Repeat MRI demonstrated optic nerve sheath (ONS) involvement suggestive of optic perineuritis (OPN) and an ONS biopsy confirmed a rare case of isolated metastatic melanoma. Our case highlights the clinical and radiographic features that can mimic OPN and delay diagnosis and treatment.",

keywords = "Metastatic melanoma, ocular melanoma, ocular metastases, optic nerve sheath, optic perineuritis",

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AU - D’souza, Neil M.

AU - Nguyen, Huy D.

AU - Smith, Stacy V.

AU - Nagarajan, Priyadharsini

AU - Diab, Adi

AU - Allen, Richard C.

AU - Gombos, Dan S.

AU - Lee, Andrew G.

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AB - A 23-year-old man with a history of metastatic melanoma developed painful vision loss to counting fingers with enhancement of optic nerve on contrast-enhanced magnetic resonance imaging (MRI) and received a diagnosis of optic neuritis from an outside hospital. Despite empiric corticosteroid therapy, the patient worsened and developed secondary central retinal vein occlusion with further deterioration of vision. Repeat MRI demonstrated optic nerve sheath (ONS) involvement suggestive of optic perineuritis (OPN) and an ONS biopsy confirmed a rare case of isolated metastatic melanoma. Our case highlights the clinical and radiographic features that can mimic OPN and delay diagnosis and treatment.

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KW - ocular melanoma

KW - ocular metastases

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Metastatic Melanoma of the Optic Nerve Sheath

Abstract

Keywords

ASJC Scopus subject areas

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