TY - JOUR
T1 - Microbiome influencers of checkpoint blockade–associated toxicity
AU - Wang, Yinghong
AU - Jenq, Robert R.
AU - Wargo, Jennifer A.
AU - Watowich, Stephanie S.
N1 - Funding Information:
This work was supported by grants from National Institutes of Health (R01AI133822 and R56AI109294 to S.S. Watowich).
Publisher Copyright:
© 2023 Wang et al.
PY - 2023/3/6
Y1 - 2023/3/6
N2 - Immunotherapy has greatly improved cancer outcomes, yet variability in response and off-target tissue damage can occur with these treatments, including immune checkpoint inhibitors (ICIs). Multiple lines of evidence indicate the host microbiome influences ICI response and risk of immune-related adverse events (irAEs). As the microbiome is modifiable, these advances indicate the potential to manipulate microbiome components to increase ICI success. We discuss microbiome features associated with ICI response, with focus on bacterial taxa and potential immune mechanisms involved in irAEs, and the overall goal of driving novel approaches to manipulate the microbiome to improve ICI efficacy while avoiding irAE risk.
AB - Immunotherapy has greatly improved cancer outcomes, yet variability in response and off-target tissue damage can occur with these treatments, including immune checkpoint inhibitors (ICIs). Multiple lines of evidence indicate the host microbiome influences ICI response and risk of immune-related adverse events (irAEs). As the microbiome is modifiable, these advances indicate the potential to manipulate microbiome components to increase ICI success. We discuss microbiome features associated with ICI response, with focus on bacterial taxa and potential immune mechanisms involved in irAEs, and the overall goal of driving novel approaches to manipulate the microbiome to improve ICI efficacy while avoiding irAE risk.
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U2 - 10.1084/jem.20220948
DO - 10.1084/jem.20220948
M3 - Review article
C2 - 36622383
AN - SCOPUS:85145956126
SN - 0022-1007
VL - 220
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
M1 - e20220948
ER -