TY - JOUR
T1 - Microbiome-intestine cross talk during acute graft-versus-host disease
AU - Rafei, Hind
AU - Jenq, Robert R.
N1 - Publisher Copyright:
© 2020 by The American Society of Hematology
PY - 2020/7/23
Y1 - 2020/7/23
N2 - Allogeneic hematopoietic stem cell transplantation (allo-SCT) offers cure for a variety of conditions, in particular, but not limited to, hematologic malignancies. However, it can be associated with life-threatening complications, including graft-versus-host disease (GVHD) and infections, which are factors limiting its widespread use. Technical advances in the field of microbiome research have allowed for a better understanding of the microbial flora of the human intestine, as well as dissection of their interactions with the host immune system in allo-SCT and posttransplant complications. There is growing evidence that the commensal microbiome is frequently dysregulated following allo-SCT and that this dysbiosis can predispose to adverse clinical outcomes, especially including acute intestinal GVHD and reduced overall survival. In this review, we discuss the interactions between the microbiome and the components of the immune system that play a major role in the pathways leading to the inflammatory state of acute intestinal GVHD. We also discuss the microbiome-centered strategies that have been devised or are actively being investigated to improve the outcomes of allo-SCT patients in regard to acute intestinal GVHD.
AB - Allogeneic hematopoietic stem cell transplantation (allo-SCT) offers cure for a variety of conditions, in particular, but not limited to, hematologic malignancies. However, it can be associated with life-threatening complications, including graft-versus-host disease (GVHD) and infections, which are factors limiting its widespread use. Technical advances in the field of microbiome research have allowed for a better understanding of the microbial flora of the human intestine, as well as dissection of their interactions with the host immune system in allo-SCT and posttransplant complications. There is growing evidence that the commensal microbiome is frequently dysregulated following allo-SCT and that this dysbiosis can predispose to adverse clinical outcomes, especially including acute intestinal GVHD and reduced overall survival. In this review, we discuss the interactions between the microbiome and the components of the immune system that play a major role in the pathways leading to the inflammatory state of acute intestinal GVHD. We also discuss the microbiome-centered strategies that have been devised or are actively being investigated to improve the outcomes of allo-SCT patients in regard to acute intestinal GVHD.
UR - http://www.scopus.com/inward/record.url?scp=85088610882&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088610882&partnerID=8YFLogxK
U2 - 10.1182/blood.2019000950
DO - 10.1182/blood.2019000950
M3 - Review article
C2 - 32526029
AN - SCOPUS:85088610882
SN - 0006-4971
VL - 136
SP - 401
EP - 409
JO - Blood
JF - Blood
IS - 4
ER -