TY - CHAP
T1 - MicroRNA and Metastasis
AU - Ma, L.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016
Y1 - 2016
N2 - Noncoding RNAs are important regulatory molecules of cellular processes. MicroRNAs (miRNAs) are small noncoding RNAs that bind to complementary sequences in the 3′ untranslated region of target mRNAs, leading to degradation of the target mRNAs and/or inhibition of their translation. Some miRNAs are essential for normal animal development; however, many other miRNAs are dispensable for development but play a critical role in pathological conditions, including tumorigenesis and metastasis. miRNA genes often reside at fragile chromosome sites and are deregulated in cancer. Some miRNAs function as oncogenes or tumor suppressors, collectively termed “oncomirs.” Specific metastasis-regulating miRNAs, collectively termed “metastamirs,” govern molecular processes and pathways in malignant progression in either a tumor cell-autonomous or a cell-nonautonomous manner. Recently, exosome-transferred miRNAs have emerged as mediators of the tumor-stroma cross talk. In this chapter, we focus on the functions, mechanisms of action, and therapeutic potential of miRNAs, particularly oncomirs and metastamirs.
AB - Noncoding RNAs are important regulatory molecules of cellular processes. MicroRNAs (miRNAs) are small noncoding RNAs that bind to complementary sequences in the 3′ untranslated region of target mRNAs, leading to degradation of the target mRNAs and/or inhibition of their translation. Some miRNAs are essential for normal animal development; however, many other miRNAs are dispensable for development but play a critical role in pathological conditions, including tumorigenesis and metastasis. miRNA genes often reside at fragile chromosome sites and are deregulated in cancer. Some miRNAs function as oncogenes or tumor suppressors, collectively termed “oncomirs.” Specific metastasis-regulating miRNAs, collectively termed “metastamirs,” govern molecular processes and pathways in malignant progression in either a tumor cell-autonomous or a cell-nonautonomous manner. Recently, exosome-transferred miRNAs have emerged as mediators of the tumor-stroma cross talk. In this chapter, we focus on the functions, mechanisms of action, and therapeutic potential of miRNAs, particularly oncomirs and metastamirs.
KW - Epithelial–mesenchymal transition
KW - Metastamir
KW - Metastasis
KW - MicroRNA
KW - Oncomir
UR - http://www.scopus.com/inward/record.url?scp=84994247303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994247303&partnerID=8YFLogxK
U2 - 10.1016/bs.acr.2016.07.004
DO - 10.1016/bs.acr.2016.07.004
M3 - Chapter
C2 - 27613133
AN - SCOPUS:84994247303
T3 - Advances in Cancer Research
SP - 165
EP - 207
BT - Advances in Cancer Research
PB - Academic Press Inc.
ER -