MicroRNA history: Discovery, recent applications, and next frontiers

Maria I. Almeida, Rui M. Reis, George A. Calin

Research output: Contribution to journalShort surveypeer-review

318 Scopus citations

Abstract

Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addition, we examine microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume717
Issue number1-2
DOIs
StatePublished - Dec 1 2011

Keywords

  • Cancer
  • History
  • MicroRNAs

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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