MicroRNA identification in plasma and serum: A new tool to diagnose and monitor diseases

Maria Angelica Cortez; George Adrian Calin

doi:10.1517/14712590902932889

MicroRNA identification in plasma and serum: A new tool to diagnose and monitor diseases

Maria Angelica Cortez, George Adrian Calin

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

370 Scopus citations

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level by degrading or blocking translation of messenger RNA (mRNA) targets. MiRNAs play important regulatory roles in a variety of cellular functions as well as in several diseases, including cancer. MiRNA-specific expression profiles have been reported for several pathological conditions. Recently, the discovery of miRNAs in serum opens up the possibility of using miRNAs as biomarkers of disease. In this review, we discuss the potential use of miRNAs as clinically diagnostic biomarkers of various cancers and other diseases as well as the approaches used to detect these molecules in serum and plasma.

Original language	English (US)
Pages (from-to)	703-711
Number of pages	9
Journal	Expert Opinion on Biological Therapy
Volume	9
Issue number	6
DOIs	https://doi.org/10.1517/14712590902932889
State	Published - Jun 2009

Keywords

Cancer
Plasma
Serum
microRNA

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1517/14712590902932889

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title = "MicroRNA identification in plasma and serum: A new tool to diagnose and monitor diseases",

abstract = "MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level by degrading or blocking translation of messenger RNA (mRNA) targets. MiRNAs play important regulatory roles in a variety of cellular functions as well as in several diseases, including cancer. MiRNA-specific expression profiles have been reported for several pathological conditions. Recently, the discovery of miRNAs in serum opens up the possibility of using miRNAs as biomarkers of disease. In this review, we discuss the potential use of miRNAs as clinically diagnostic biomarkers of various cancers and other diseases as well as the approaches used to detect these molecules in serum and plasma.",

keywords = "Cancer, Plasma, Serum, microRNA",

author = "Cortez, {Maria Angelica} and Calin, {George Adrian}",

note = "Funding Information: Dr Calin is supported as a fellow of The University of Texas M. D. Anderson Research Trust, as a University of Texas System Regents Research Scholar and by the Ladjevardian Regents Research Scholar Fund. This study was partly funded also by an Institutional Research Grant and by a CCSG (New Faculty Award) to Dr Calin.",

year = "2009",

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doi = "10.1517/14712590902932889",

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AU - Cortez, Maria Angelica

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PY - 2009/6

Y1 - 2009/6

N2 - MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level by degrading or blocking translation of messenger RNA (mRNA) targets. MiRNAs play important regulatory roles in a variety of cellular functions as well as in several diseases, including cancer. MiRNA-specific expression profiles have been reported for several pathological conditions. Recently, the discovery of miRNAs in serum opens up the possibility of using miRNAs as biomarkers of disease. In this review, we discuss the potential use of miRNAs as clinically diagnostic biomarkers of various cancers and other diseases as well as the approaches used to detect these molecules in serum and plasma.

AB - MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level by degrading or blocking translation of messenger RNA (mRNA) targets. MiRNAs play important regulatory roles in a variety of cellular functions as well as in several diseases, including cancer. MiRNA-specific expression profiles have been reported for several pathological conditions. Recently, the discovery of miRNAs in serum opens up the possibility of using miRNAs as biomarkers of disease. In this review, we discuss the potential use of miRNAs as clinically diagnostic biomarkers of various cancers and other diseases as well as the approaches used to detect these molecules in serum and plasma.

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KW - Plasma

KW - Serum

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MicroRNA identification in plasma and serum: A new tool to diagnose and monitor diseases

Abstract

Keywords

ASJC Scopus subject areas

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