microRNA Therapeutics in Cancer — An Emerging Concept

Maitri Y. Shah; Alessandra Ferrajoli; Anil K. Sood; Gabriel Lopez-Berestein; George A. Calin

doi:10.1016/j.ebiom.2016.09.017

microRNA Therapeutics in Cancer — An Emerging Concept

Maitri Y. Shah, Alessandra Ferrajoli, Anil K. Sood, Gabriel Lopez-Berestein, George A. Calin

Research output: Contribution to journal › Review article › peer-review

344 Scopus citations

Abstract

MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular processes, and they play a vital role in tumor initiation, progression and metastasis. Further, widespread deregulation of microRNAs have been reported in several cancers, with several microRNAs playing oncogenic and tumor suppressive roles. Based on these, miRNAs have emerged as promising therapeutic tools for cancer management. In this review, we have focused on the roles of miRNAs in tumorigenesis, the miRNA-based therapeutic strategies currently being evaluated for use in cancer, and the advantages and current challenges to their use in the clinic.

Original language	English (US)
Pages (from-to)	34-42
Number of pages	9
Journal	EBioMedicine
Volume	12
DOIs	https://doi.org/10.1016/j.ebiom.2016.09.017
State	Published - Oct 1 2016

Keywords

Cancer
Clinical trials
Non-coding RNA
Therapeutics
microRNA

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.ebiom.2016.09.017

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title = "microRNA Therapeutics in Cancer — An Emerging Concept",

abstract = "MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular processes, and they play a vital role in tumor initiation, progression and metastasis. Further, widespread deregulation of microRNAs have been reported in several cancers, with several microRNAs playing oncogenic and tumor suppressive roles. Based on these, miRNAs have emerged as promising therapeutic tools for cancer management. In this review, we have focused on the roles of miRNAs in tumorigenesis, the miRNA-based therapeutic strategies currently being evaluated for use in cancer, and the advantages and current challenges to their use in the clinic.",

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AU - Shah, Maitri Y.

AU - Ferrajoli, Alessandra

AU - Sood, Anil K.

AU - Lopez-Berestein, Gabriel

AU - Calin, George A.

PY - 2016/10/1

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AB - MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular processes, and they play a vital role in tumor initiation, progression and metastasis. Further, widespread deregulation of microRNAs have been reported in several cancers, with several microRNAs playing oncogenic and tumor suppressive roles. Based on these, miRNAs have emerged as promising therapeutic tools for cancer management. In this review, we have focused on the roles of miRNAs in tumorigenesis, the miRNA-based therapeutic strategies currently being evaluated for use in cancer, and the advantages and current challenges to their use in the clinic.

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KW - Clinical trials

KW - Non-coding RNA

KW - Therapeutics

KW - microRNA

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microRNA Therapeutics in Cancer — An Emerging Concept

Abstract

Keywords

ASJC Scopus subject areas

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