MicroRNAs and metastasis: small RNAs play big roles

Jongchan Kim, Fan Yao, Zhenna Xiao, Yutong Sun, Li Ma

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs regulating post-transcriptional gene expression. They play important roles in many biological processes under physiological or pathological conditions, including development, metabolism, tumorigenesis, metastasis, and immune response. Over the past 15 years, significant insights have been gained into the roles of miRNAs in cancer. Depending on the cancer type, miRNAs can act as oncogenes, tumor suppressors, or metastasis regulators. In this review, we focus on the role of miRNAs as components of molecular networks regulating metastasis. These miRNAs, termed metastamiRs, promote or inhibit metastasis through various mechanisms, including regulation of migration, invasion, colonization, cancer stem cell properties, epithelial-mesenchymal transition, and microenvironment. Some of these metastamiRs represent attractive therapeutic targets for cancer treatment.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalCancer and Metastasis Reviews
Volume37
Issue number1
DOIs
StatePublished - Mar 1 2018

Fingerprint

MicroRNAs
RNA
Neoplasm Metastasis
Neoplasms
Biological Phenomena
Small Untranslated RNA
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Oncogenes
Carcinogenesis
Gene Expression
Therapeutics

Keywords

  • MetastamiR
  • Metastasis
  • MicroRNA (miRNA)
  • OncomiR

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

MicroRNAs and metastasis : small RNAs play big roles. / Kim, Jongchan; Yao, Fan; Xiao, Zhenna; Sun, Yutong; Ma, Li.

In: Cancer and Metastasis Reviews, Vol. 37, No. 1, 01.03.2018, p. 5-15.

Research output: Contribution to journalArticle

Kim, Jongchan ; Yao, Fan ; Xiao, Zhenna ; Sun, Yutong ; Ma, Li. / MicroRNAs and metastasis : small RNAs play big roles. In: Cancer and Metastasis Reviews. 2018 ; Vol. 37, No. 1. pp. 5-15.
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