@inbook{78b861ea02c64480bd9c599a58b14712,
title = "MicroRNAs in cancer. From bench to bedside",
abstract = "microRNAs (miRNAs) are master regulators of gene expression. By degrading or blocking translation of messenger RNA targets, these noncoding RNAs can regulate the expression of more than half of all protein-coding genes in mammalian genomes. Aberrant miRNA expression is well characterized in cancer progression and has prognostic implications for cancer in general. Over the past several years, accumulating evidence has demonstrated that genomic alterations in miRNA genes are correlated with all aspects of cancer biology. In this review, we describe the effects of miRNA deregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells as well as in cancer diagnosis and therapy in humans.",
author = "{Angelica Cortez}, Maria and Cristina Ivan and Peng Zhou and Xue Wu and Mircea Ivan and {Adrian Calin}, George",
note = "Funding Information: G.A.C. is supported as a fellow at The University of Texas M. D. Anderson Research Trust, as a fellow of The University of Texas System Regents Research Scholar, and by the Ladjevardian Regents Research Scholar Fund. Work in Dr Calin's laboratory is supported in part by an NIH RO1 grant, by a DOD Breast Cancer Idea Award, by a Breast Cancer SPORE Developmental Research Award, by an Ovarian Cancer SPORE Developmental Research Award, by a CTT/3I-TD grant, and by 2009 Seena Magowitz—Pancreatic Cancer Action Network—AACR Pilot Grant. M.I. is an American Cancer Society Research Scholar.",
year = "2010",
doi = "10.1016/B978-0-12-380888-2.00004-2",
language = "English (US)",
series = "Advances in Cancer Research",
publisher = "Academic Press Inc.",
number = "C",
pages = "113--157",
booktitle = "Advances in Cancer Research",
edition = "C",
}