Micrornas in solid tumors

Subrata Sen, Jin Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs (17–25 nt) that modulate the expression of genes by negatively regulating translation and stability of messenger RNAs (mRNAs). miRNAs have emerged as critical players in cancer initiation and progression processes due to their documented roles in either promoting (oncogenic) or suppressing (tumor-suppressors) oncogenesis. Dysregulation of miRNA expression levels and associated alterations in gene expressions have been demonstrated in various solid tumors. In this chapter, biogenesis of miRNAs and dysregulation of miRNAs in tumor formation, maintenance and metastasis as well as potential role of miRNAs as cancer biomarkers and therapeutic targets for anticancer treatment are discussed.

Original languageEnglish (US)
Title of host publicationNon-Coding RNAs and Cancer
PublisherSpringer New York
Pages45-65
Number of pages21
ISBN (Electronic)9781461484448
ISBN (Print)9781461484431
DOIs
StatePublished - Jan 1 2014

Keywords

  • Biomarkers
  • Cancer therapy
  • Diagnosis and prognosis
  • MiRNAs
  • Oncomirs
  • Solid tumors

ASJC Scopus subject areas

  • General Medicine

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