Abstract
MicroRNAs (miRNAs) are small noncoding RNAs (17–25 nt) that modulate the expression of genes by negatively regulating translation and stability of messenger RNAs (mRNAs). miRNAs have emerged as critical players in cancer initiation and progression processes due to their documented roles in either promoting (oncogenic) or suppressing (tumor-suppressors) oncogenesis. Dysregulation of miRNA expression levels and associated alterations in gene expressions have been demonstrated in various solid tumors. In this chapter, biogenesis of miRNAs and dysregulation of miRNAs in tumor formation, maintenance and metastasis as well as potential role of miRNAs as cancer biomarkers and therapeutic targets for anticancer treatment are discussed.
Original language | English (US) |
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Title of host publication | Non-Coding RNAs and Cancer |
Publisher | Springer New York |
Pages | 45-65 |
Number of pages | 21 |
ISBN (Electronic) | 9781461484448 |
ISBN (Print) | 9781461484431 |
DOIs | |
State | Published - Jan 1 2014 |
Keywords
- Biomarkers
- Cancer therapy
- Diagnosis and prognosis
- MiRNAs
- Oncomirs
- Solid tumors
ASJC Scopus subject areas
- General Medicine