Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo

Soo Mi Kweon, Gayeoun Kim, Yunseong Jeong, Wendong Huang, Ju Seog Lee, Keane K.Y. Lai

Research output: Contribution to journalArticlepeer-review


Hepatocellular carcinoma (HCC) ranks worldwide as one of the most lethal cancers. In spite of the vast existing knowledge about HCC, the pathogenesis of HCC is not completely understood. Discovery of novel genes that contribute to HCC pathogenesis will provide new insights for better understanding and treating HCC. The relatively obscure gene midnolin has been studied for over two decades; however, its biological roles are largely unknown. Our study is the first to demonstrate the functional significance of midnolin in HCC/cancer: Midnolin expression correlates with poor prognosis in HCC patients, and suppression of midnolin severely inhibits tumorigenicity of HCC cells in vitro and in mice and disrupts retinoic acid/lipid metabolism in these cells.

Original languageEnglish (US)
Article number1421
Issue number6
StatePublished - Mar 1 2022


  • Hepatocellular carcinoma
  • Liver cancer
  • Liver carcinogenesis
  • Midnolin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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