@article{2499a7255913423e8c951c9921c65975,
title = "Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo",
abstract = "Hepatocellular carcinoma (HCC) ranks worldwide as one of the most lethal cancers. In spite of the vast existing knowledge about HCC, the pathogenesis of HCC is not completely understood. Discovery of novel genes that contribute to HCC pathogenesis will provide new insights for better understanding and treating HCC. The relatively obscure gene midnolin has been studied for over two decades; however, its biological roles are largely unknown. Our study is the first to demonstrate the functional significance of midnolin in HCC/cancer: Midnolin expression correlates with poor prognosis in HCC patients, and suppression of midnolin severely inhibits tumorigenicity of HCC cells in vitro and in mice and disrupts retinoic acid/lipid metabolism in these cells.",
keywords = "Hepatocellular carcinoma, Liver cancer, Liver carcinogenesis, Midnolin",
author = "Kweon, {Soo Mi} and Gayeoun Kim and Yunseong Jeong and Wendong Huang and Lee, {Ju Seog} and Lai, {Keane K.Y.}",
note = "Funding Information: This work was supported by the National Cancer Institute and the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health (R01CA237327 to J.-S.L.; K08AA025112 to K.K.Y.L.; R01CA139158 to W.H.; P30CA033572; and T32CA221709).Acknowledgments: The authors thank Michael Kahn of City of Hope for scientific discussion and provision of study materials/reagents. The authors also thank Chih-Hong Lou, Walter M. Tsark, James B. Finlay, Patrick T. Fueger, Elizabeth Melendez, Sheng-Wei Chang (supported by T32CA221709), Jinhui Wang, Yate-Ching Yuan, Wei Chen, and Xiwei Wu of City of Hope for scientific discussion and technical assistance, David P. Lin for assistance with illustration/graphics, and Keith K. Lai of the Cleveland Clinic for gastrointestinal pathologist review of histology. Funding Information: Funding: This work was supported by the National Cancer Institute and the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health (R01CA237327 to J.-S.L.; K08AA025112 to K.K.Y.L.; R01CA139158 to W.H.; P30CA033572; and T32CA221709). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = mar,
day = "1",
doi = "10.3390/cancers14061421",
language = "English (US)",
volume = "14",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}