Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution Is Highly Effective In Vitro for Eradication of Candida auris Biofilms

Ruth A. Reitzel; Joel Rosenblatt; Bahgat Z. Gerges; Nylev Vargas-Cruz; Issam I. Raad

doi:10.1128/AAC.02146-19

Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution Is Highly Effective In Vitro for Eradication of Candida auris Biofilms

Ruth A. Reitzel, Joel Rosenblatt, Bahgat Z. Gerges, Nylev Vargas-Cruz, Issam I. Raad

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofilms of 10 C. auris strains. MEE fully eradicated all C. auris biofilms, while taurolidine lock partially eradicated all of the C. auris biofilms. The superiority was significant for all C. auris strains tested (P = 0.002).

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	64
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02146-19
State	Published - Mar 24 2020

Keywords

antimicrobial agents
biofilm
Candida auris
catheter lock solution
minocycline-EDTA-ethanol

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.02146-19

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abstract = "Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofilms of 10 C. auris strains. MEE fully eradicated all C. auris biofilms, while taurolidine lock partially eradicated all of the C. auris biofilms. The superiority was significant for all C. auris strains tested (P = 0.002).",

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AU - Vargas-Cruz, Nylev

AU - Raad, Issam I.

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AB - Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofilms of 10 C. auris strains. MEE fully eradicated all C. auris biofilms, while taurolidine lock partially eradicated all of the C. auris biofilms. The superiority was significant for all C. auris strains tested (P = 0.002).

KW - antimicrobial agents

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KW - minocycline-EDTA-ethanol

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Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution Is Highly Effective In Vitro for Eradication of Candida auris Biofilms

Abstract

Keywords

ASJC Scopus subject areas

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