MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

Ji Heon Noh; Young Gyoon Chang; Min Gyu Kim; Kwang Hwa Jung; Jeong Kyu Kim; Hyun Jin Bae; Jung Woo Eun; Qingyu Shen; Seung Jin Kim; So Hee Kwon; Won Sang Park; Jung Young Lee; Suk Woo Nam

doi:10.1016/j.canlet.2013.03.003

MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

Ji Heon Noh
, Young Gyoon Chang
, Min Gyu Kim
, Kwang Hwa Jung
, Jeong Kyu Kim
, Hyun Jin Bae
, Jung Woo Eun
, Qingyu Shen
, Seung Jin Kim
, So Hee Kwon
, Won Sang Park
, Jung Young Lee
, Suk Woo Nam

Molecular & Cellular Oncology

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis.

Original language	English (US)
Pages (from-to)	455-462
Number of pages	8
Journal	Cancer Letters
Volume	335
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2013.03.003
State	Published - Jul 28 2013

Keywords

HDAC2
Liver cancer
MiR-145
Tumor suppressor

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2013.03.003

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@article{6398e8a6b09d4b74af1752ee7d3b7fb8,

title = "MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer",

abstract = "Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis.",

keywords = "HDAC2, Liver cancer, MiR-145, Tumor suppressor",

author = "Noh, \{Ji Heon\} and Chang, \{Young Gyoon\} and Kim, \{Min Gyu\} and Jung, \{Kwang Hwa\} and Kim, \{Jeong Kyu\} and Bae, \{Hyun Jin\} and Eun, \{Jung Woo\} and Qingyu Shen and Kim, \{Seung Jin\} and Kwon, \{So Hee\} and Park, \{Won Sang\} and Lee, \{Jung Young\} and Nam, \{Suk Woo\}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) (Grant Nos. 2011-0010705 and 2012M3A9D1054476 ), and by the Korean Science and Engineering Foundation via the {\textquotedblleft}Cancer Evolution Research Center{\textquotedblright} at The Catholic University of Korea. ",

year = "2013",

month = jul,

day = "28",

doi = "10.1016/j.canlet.2013.03.003",

language = "English (US)",

volume = "335",

pages = "455--462",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

AU - Noh, Ji Heon

AU - Chang, Young Gyoon

AU - Kim, Min Gyu

AU - Jung, Kwang Hwa

AU - Kim, Jeong Kyu

AU - Bae, Hyun Jin

AU - Eun, Jung Woo

AU - Shen, Qingyu

AU - Kim, Seung Jin

AU - Kwon, So Hee

AU - Park, Won Sang

AU - Lee, Jung Young

AU - Nam, Suk Woo

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) (Grant Nos. 2011-0010705 and 2012M3A9D1054476 ), and by the Korean Science and Engineering Foundation via the “Cancer Evolution Research Center” at The Catholic University of Korea.

PY - 2013/7/28

Y1 - 2013/7/28

N2 - Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis.

AB - Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis.

KW - HDAC2

KW - Liver cancer

KW - MiR-145

KW - Tumor suppressor

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UR - https://www.scopus.com/pages/publications/84878249332#tab=citedBy

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DO - 10.1016/j.canlet.2013.03.003

M3 - Article

C2 - 23499894

AN - SCOPUS:84878249332

SN - 0304-3835

VL - 335

SP - 455

EP - 462

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

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Keywords

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