Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Gui fang Zhu; Yang wei Xu; Jian Li; Hui lin Niu; Wen xia Ma; Jia Xu; Pei rong Zhou; Xia Liu; Dan li Ye; Xiao rong Liu; Tao Yan; Wei ke Zhai; Zhi jun Xu; Chun Liu; Lei Wang; Hao Wang; Jia mao Luo; Li Liu; Xuan qi Li; Suiqun Guo; Hui ping Jiang; Peng Shen; Hui kuan Lin; Di hua Yu; Yan qing Ding; Qing ling Zhang

doi:10.1038/s41467-018-07998-x

Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Gui fang Zhu, Yang wei Xu, Jian Li, Hui lin Niu, Wen xia Ma, Jia Xu, Pei rong Zhou, Xia Liu, Dan li Ye, Xiao rong Liu, Tao Yan, Wei ke Zhai, Zhi jun Xu, Chun Liu, Lei Wang, Hao Wang, Jia mao Luo, Li Liu, Xuan qi Li, Suiqun GuoHui ping Jiang, Peng Shen, Hui kuan Lin, Di hua Yu, Yan qing Ding, Qing ling Zhang

Molecular & Cellular Oncology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated that WTX frequently lost in CRC which was highly correlated with cell proliferation, tumor invasion and metastasis. Mechanistically, WTX loss disrupts the interaction between RhoGDIα and CDC42 by losing of the binding with RhoGDIα and triggers the activation of CDC42 and its downstream cascades, which promotes CRC development and liver metastasis. The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression.

Original language	English (US)
Article number	112
Journal	Nature communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-07998-x
State	Published - Dec 1 2019

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Zhu, G. F., Xu, Y. W., Li, J., Niu, H. L., Ma, W. X., Xu, J., Zhou, P. R., Liu, X., Ye, D. L., Liu, X. R., Yan, T., Zhai, W. K., Xu, Z. J., Liu, C., Wang, L., Wang, H., Luo, J. M., Liu, L., Li, X. Q., ... Zhang, Q. L. (2019). Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression. Nature communications, 10(1), Article 112. https://doi.org/10.1038/s41467-018-07998-x

Zhu, GF, Xu, YW, Li, J, Niu, HL, Ma, WX, Xu, J, Zhou, PR, Liu, X, Ye, DL, Liu, XR, Yan, T, Zhai, WK, Xu, ZJ, Liu, C, Wang, L, Wang, H, Luo, JM, Liu, L, Li, XQ, Guo, S, Jiang, HP, Shen, P, Lin, HK, Yu, DH, Ding, YQ & Zhang, QL 2019, 'Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression', Nature communications, vol. 10, no. 1, 112. https://doi.org/10.1038/s41467-018-07998-x

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title = "Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression",

abstract = "Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated that WTX frequently lost in CRC which was highly correlated with cell proliferation, tumor invasion and metastasis. Mechanistically, WTX loss disrupts the interaction between RhoGDIα and CDC42 by losing of the binding with RhoGDIα and triggers the activation of CDC42 and its downstream cascades, which promotes CRC development and liver metastasis. The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression.",

author = "Zhu, {Gui fang} and Xu, {Yang wei} and Jian Li and Niu, {Hui lin} and Ma, {Wen xia} and Jia Xu and Zhou, {Pei rong} and Xia Liu and Ye, {Dan li} and Liu, {Xiao rong} and Tao Yan and Zhai, {Wei ke} and Xu, {Zhi jun} and Chun Liu and Lei Wang and Hao Wang and Luo, {Jia mao} and Li Liu and Li, {Xuan qi} and Suiqun Guo and Jiang, {Hui ping} and Peng Shen and Lin, {Hui kuan} and Yu, {Di hua} and Ding, {Yan qing} and Zhang, {Qing ling}",

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doi = "10.1038/s41467-018-07998-x",

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T1 - Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

AU - Zhu, Gui fang

AU - Xu, Yang wei

AU - Li, Jian

AU - Niu, Hui lin

AU - Ma, Wen xia

AU - Xu, Jia

AU - Zhou, Pei rong

AU - Liu, Xia

AU - Ye, Dan li

AU - Liu, Xiao rong

AU - Yan, Tao

AU - Zhai, Wei ke

AU - Xu, Zhi jun

AU - Liu, Chun

AU - Wang, Lei

AU - Wang, Hao

AU - Luo, Jia mao

AU - Liu, Li

AU - Li, Xuan qi

AU - Guo, Suiqun

AU - Jiang, Hui ping

AU - Shen, Peng

AU - Lin, Hui kuan

AU - Yu, Di hua

AU - Ding, Yan qing

AU - Zhang, Qing ling

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated that WTX frequently lost in CRC which was highly correlated with cell proliferation, tumor invasion and metastasis. Mechanistically, WTX loss disrupts the interaction between RhoGDIα and CDC42 by losing of the binding with RhoGDIα and triggers the activation of CDC42 and its downstream cascades, which promotes CRC development and liver metastasis. The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression.

AB - Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated that WTX frequently lost in CRC which was highly correlated with cell proliferation, tumor invasion and metastasis. Mechanistically, WTX loss disrupts the interaction between RhoGDIα and CDC42 by losing of the binding with RhoGDIα and triggers the activation of CDC42 and its downstream cascades, which promotes CRC development and liver metastasis. The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression.

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Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

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